Publications by authors named "Karlijn L Kooij"
Article Synopsis
- The study investigates how gut microbiota from patients with anorexia nervosa (AN) affects anxiety, cognitive flexibility, and dopamine signaling in rats through fecal microbiota transplantation (FMT).
- Results showed no significant changes in cognition or dopamine activity after receiving microbiota from AN patients compared to controls, although antibiotic treatment lowered task engagement in the rats.
- The findings suggest that while AN-associated gut microbiota may not directly influence cognitive flexibility, the limitations of the FMT methods used indicate a need for better experimental protocols in future research.
The atypical antipsychotic drug olanzapine is prescribed despite clinical studies on olanzapine treatment showing mixed results on treatment efficacy in anorexia nervosa. We investigated the effect of systemic and intranasal administration of olanzapine in the activity-based anorexia (ABA) model. Rats were habituated to a running wheel and exposed to the ABA model while treated with olanzapine.
View Article and Find Full Text PDFBackground: Anorexia nervosa (AN) is a severe psychiatric disease that often takes a chronic course due to insufficient treatment options. Emerging evidence on the gut-brain axis offers the opportunity to find innovative treatments for patients with psychiatric disorders. The gut microbiome of patients with AN shows profound alterations that do not completely disappear after weight rehabilitation.
View Article and Find Full Text PDFThe effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa-A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial.
Eur Eat Disord Rev
January 2022
Objective: Knowledge on gut-brain interaction might help to develop new therapies for patients with anorexia nervosa (AN), as severe starvation-induced changes of the microbiome (MI) do not normalise with weight gain. We examine the effects of probiotics supplementation on the gut MI in patients with AN.
Method: This is a study protocol for a two-centre double-blind randomized-controlled trial comparing the clinical efficacy of multistrain probiotic administration in addition to treatment-as-usual compared to placebo in 60 patients with AN (13-19 years).