Prostaglandin F drives female pheromone signaling in cichlids, revealing a basis for evolutionary divergence in olfactory signaling.

Pheromones play essential roles in reproduction in many species. Prostaglandin F (PGF) acts as a female reproductive hormone and as a sex pheromone in some species. An olfactory receptor (OR) for PGF was recently discovered in zebrafish, but this signaling pathway is evolutionarily labile.