Publications by authors named "Karla S Mabrey"
Mol Pharmacol
February 2015
Article Synopsis
- Proliferating cell nuclear antigen (PCNA) is crucial for DNA replication and repair, and its modification can impact cancer cell processes, particularly in breast cancer.
- A new peptide, R9-cc-caPeptide, mimics a cancer-specific region of PCNA and demonstrates cytotoxic effects on triple-negative breast cancer cells, indicating potential for targeted therapy.
- The peptide has shown effectiveness against various cancer types and works by disrupting PCNA's association with chromatin, with research backing its mechanism through experimental assays and modeling.
