Publications by authors named "Karla Ramirez-Sanchez"

Article Synopsis
  • Researchers developed starch-based porous cryogels aimed at tissue engineering, combining materials like κ-carrageenan, PVA, and SbQ.
  • They created a conductive version of the cryogel by oxidizing EDOT to enhance electrical properties, utilizing iron(III) p-toluenesulfonate.
  • Tests showed that varying biopolymer content could effectively tune the cryogel's mechanical properties, with κ-carrageenan enhancing stiffness and PVA acting as a plasticizer, while cross-linking with PVA-SBQ further improved these properties.
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In this work, the effect of iron(III) in the preparation of a conductive porous composite using a biomass waste-based starch template was evaluated. Biopolymers are obtained from natural sources, for instance, starch from potato waste, and its conversion into value-added products is highly significant in a circular economy. The biomass starch-based conductive cryogel was polymerized via chemical oxidation of 3,4-ethylenedioxythiophene (EDOT) using iron(III) p-toluenesulfonate as a strategy to functionalize porous biopolymers.

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Recently, tissue engineering and regenerative medicine studies have evaluated smart biomaterials as implantable scaffolds and their interaction with cells for biomedical applications. Porous materials have been used in tissue engineering as synthetic extracellular matrices, promoting the attachment and migration of host cells to induce the in vitro regeneration of different tissues. Biomimetic 3D scaffold systems allow control over biophysical and biochemical cues, modulating the extracellular environment through mechanical, electrical, and biochemical stimulation of cells, driving their molecular reprogramming.

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Smart conductive materials are developed in regenerative medicine to promote a controlled release profile of charged bioactive agents in the vicinity of implants. The incorporation and the active electrochemical release of the charged compounds into the organic conductive coating is achieved due to its intrinsic electrical properties. The anti-inflammatory drug dexamethasone was added during the polymerization, and its subsequent release at therapeutic doses was reached by electrical stimulation.

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