Publications by authors named "Karla Montserrat Gil-Becerril"
Article Synopsis
- The development of amoebic liver abscess (ALA) results in liver necrosis, heightened inflammation, and granuloma formation, but with proper treatment, the liver can heal without scar tissue unlike in viral hepatitis.
- The Hedgehog signaling pathway (Hh) is vital during embryonic development and is reactivated in adults during liver injuries and healing; this study examined its role in liver regeneration in a model of ALA using treatment like metronidazole and the inhibitor cyclopamine.
- Findings revealed increased lesions, reduced newly formed hepatocytes, widespread inflammation, irregular collagen distribution, and fewer effector cells of the Hh pathway, marking the first evidence of Hh activation's link to liver regeneration in amoebiasis
Human amoebiasis still represents a major health problem worldwide. Metronidazole has been used as the most common drug to treat the disease; however, it is also known that the drug causes undesirable side effects. This has led to the search for new pharmacological alternatives which include phytochemical compounds with antiamoebic effects.
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