Publications by authors named "Karla Mariuxi Villagran-Andrade"
Article Synopsis
- * Phytonutrients from plants can help combat osteoarthritis by reducing inflammation through changes in DNA and chromatin related to inflammatory genes.
- * The review highlights the need for more research on bioactive compounds as potential treatments in osteoarthritis, aiming to personalize nutrition for better disease prevention and management.
Epigenetics as a Therapeutic Target in Osteoarthritis.
Carmen Núñez-Carro Margarita Blanco-Blanco Karla Mariuxi Villagrán-Andrade Francisco J Blanco María C de Andrés
Pharmaceuticals (Basel)
January 2023
Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important role in OA. Our objective is to review the current knowledge of the three classical epigenetic mechanisms-DNA methylation, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) modifications, including microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs)-in relation to the pathogenesis of OA and focusing on articular cartilage.
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