Expression pattern of sex steroid hormone receptors in the adult male rabbit brain.

Progesterone (P4), estradiol (E2), and testosterone (T) are crucial for reproduction and are pivotal in several vertebrate central nervous system (CNS) functions. These hormones act by binding to their corresponding receptors, including those intracellularly located, such as progesterone receptor (PR), estrogen receptor (ER), and androgen receptor, which in this manuscript we named testosterone receptor (TR). The expression pattern of these receptors in the rabbit male brain is unknown.

Expression and estrogen regulation of G protein-coupled estrogen receptor in human glioblastoma cells.

Glioblastoma (GB) is the most frequent primary brain tumor with a very poor prognosis. Sex hormones are crucial players in the development of GBs. 17 β-estradiol (E2) signaling is involved through its corresponding intracellular receptors [estrogen receptor α (ERα) and β (ERβ)] in GB cell proliferation and progression.

EZH2 Mediates Proliferation, Migration, and Invasion Promoted by Estradiol in Human Glioblastoma Cells.

Glioblastomas (GBM) are the most frequent and aggressive brain tumors. 17β-estradiol (E2) increases proliferation, migration, and invasion of human GBM cells; however underlying mechanisms are no fully understood. Zeste 2 Enhancer Homologous enzyme (EZH2) is a methyltransferase part of Polycomb 2 repressor complex (PRC2).