Current trends to design antimalarial drugs targeting -myristoyltransferase.

Malaria is a disease caused by spp., of which and are the most prevalent. Unfortunately, traditional and some current treatment regimens face growing protozoan resistance.

Targeting SmCB1: Perspectives and Insights to Design Antischistosomal Drugs.

Neglected tropical diseases (NTDs) are prevalent in tropical and subtropical countries, and schistosomiasis is among the most relevant diseases worldwide. In addition, one of the two biggest problems in developing drugs against this disease is related to drug resistance, which promotes the demand to develop new drug candidates for this purpose. Thus, one of the drug targets most explored, Cathepsin B1 (SmCB1 or Sm31), provides new opportunities in drug development due to its essential functions for the parasite's survival.