Publications by authors named "Karla J Au Yeung"

Background: Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum. Previous small studies found no associations between gastrointestinal (GI) symptoms and combined low disaccharidase activity.

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Article Synopsis
  • The study evaluates the impact of the Multidisciplinary Pediatric Aerodigestive Care Team (MPACT) on pediatric patients' healthcare patterns before and after their enrollment.
  • The analysis of financial claims data revealed that there was a significant shift from inpatient to outpatient care, leading to an overall reduction in total patient charges by approximately 20%.
  • The findings also indicated a potential demand for MPACT services based on ICD-9 data, with many other pediatric patients displaying similar needs for aerodigestive care.
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Importance: Children with complex respiratory and gastrointestinal disorders frequently require care from multiple pediatric subspecialists. Interdisciplinary pediatric aerodigestive clinic centers have been established at several pediatric tertiary care centers in the United States. Their effectiveness is unknown.

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Previous studies have shown that deficiencies in selenium (Se) and/or vitamin E (VE) can exacerbate the infectivity and pathogenesis of coxsackievirus B3 and influenza. Both Se and VE play a role in immune function and antioxidant defense. To determine whether these deficiencies would affect the normal course of infection with a metazoan parasite, mice were made deficient in Se and/or VE and inoculated with the gastrointestinal nematode parasite Heligmosomoides polygyrus.

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The effects of deficiencies in the antioxidant nutrients, vitamin E and selenium, on the host response to gastrointestinal nematode infection are unknown. The aim of the study was to determine the effect of antioxidant deficiencies on nematode-induced alterations in intestinal function in mice. BALB/c mice were fed control diets or diets deficient in selenium or vitamin E and the response to a secondary challenge inoculation with Heligmosomoides polygyrus was determined.

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