Intra-tumor genetic heterogeneity in Wilms tumor samples.

Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms' tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years.

[Early diagnosis of childhood cancer: a team responsibility].

Objectives: To call attention for necessity of the knowledge of the early symptoms of childhood cancer and for the responsibility of the parents, physicians and teachers rendering health supervision to the children and to alert that the early detection and prompt treatment is of paramount importance in achieving cures in childhood cancer.

Sources: Literature review using Medline.

Summary: The diagnosis of childhood cancer is complex and many variables play an important role.