[Delayed diagnosis in retinoblastoma].

Objectives: To identify the main symptoms of retinoblastoma and to determine the mean time between symptom onset and diagnosis (lag time).

Patients And Methods: We carried out a retrospective analysis of the patients diagnosed with retinoblastoma between January 1991 and June 2000, at the Pediatric Department of the Hospital do Cancer, Sao Paulo, Brazil. Statistical analyses performed were: Student's t test, ANOVA, Tukey-HSD test (honest significant differences), Levene's test, multiple regression, ROC curve, logistic regression, Kaplan-Meier, and log rank.