Publications by authors named "Karla B Schallies"
Article Synopsis
- The cell cycle is essential for bacterial reproduction and varies based on the growth environment, showing different behaviors during free-living and symbiotic states.
- Key regulators, particularly the DivK kinase CbrA, negatively influence CtrA activity and are crucial for symbiosis; genetic mutations can restore normal cell cycle progression.
- The CckA hybrid histidine kinase, with both kinase and phosphatase functions, plays a significant role in regulating CtrA, highlighting important processes in the cell cycle and symbiotic differentiation of soil bacteria, which are vital for their agricultural relevance.
Unlabelled: CbrA is a DivJ/PleC-like histidine kinase of DivK that is required for cell cycle progression and symbiosis in the alphaproteobacterium Sinorhizobium meliloti. Loss of cbrA results in increased levels of CtrA as well as its phosphorylation. While many of the known Caulobacter crescentus regulators of CtrA phosphorylation and proteolysis are phylogenetically conserved within S.
View Article and Find Full Text PDFSinorhizobium meliloti is alternately capable of colonizing the soil as a free-living bacterium or establishing a chronic intracellular infection with its legume host for the purpose of nitrogen fixation. We previously identified the S. meliloti two-component sensor histidine kinase CbrA as playing an important role in regulating exopolysaccharide production, flagellar motility and symbiosis.
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