Publications by authors named "Karl Schettler"

Article Synopsis
  • The study investigates trends in infant mortality rates linked to extreme neonatal hyperbilirubinemia (EHB) in six European countries from 1990 to 2019, revealing a significant decline in such mortality rates over the years.
  • Results showed a decrease in EHB-related infant mortality from 21.4 to 4.2 per million live births, with Germany showing the best improvement and Portugal the most significant decline rate.
  • The findings underscore the need for national surveillance and tailored guidelines to prevent bilirubin-induced neurological damage, highlighting substantial differences in mortality trends among the countries studied.
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Neuromonitoring has been widely accepted as an important part in neonatal care. Amplitude-integrated EEG (aEEG) and near-infrared spectroscopy (NIRS) are often mentioned in this context, though being only a part of the fully array of methods and examinations that could be considered neuromonitoring. Within the broad array of medical conditions that could be encountered in a neonatal patient, it is important to be aware of the indications for neuromonitoring and especially which neuromonitoring technique to use best for the individual condition.

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Congenital disorders of glycosylation (CDG) type I include variants in the gene leading to DPM1-CDG. The nine previously reported patients showed developmental delay, seizures, electroencephalography abnormalities and dysmorphic features with varying disease onset and severity. Clinical features of a new patient are described.

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 Amplitude-integrated electroencephalography (aEEG) is one of the most widely used neuromonitoring tools in neonatology today. However, little is known about its clinical indications and potential benefits in pediatric intensive care patients. Based on limited experience, its impact on therapeutic decision-making in this patient population is unclear.

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