Sequence variant at 8q24.21 associates with sciatica caused by lumbar disc herniation.

Lumbar disc herniation (LDH) is common and often debilitating. Microdiscectomy of herniated lumbar discs (LDHsurg) is performed on the most severe cases to resolve the resulting sciatica. Here we perform a genome-wide association study on 4,748 LDHsurg cases and 282,590 population controls and discover 37 highly correlated markers associating with LDHsurg at 8q24.

Long-term development of malocclusion traits in orthodontically treated and untreated subjects.

Introduction: The purposes of this study were to analyze long-term changes in malocclusion traits and to compare the development in orthodontically treated and untreated subjects.

Methods: The sample comprised 308 adolescents in the intermediate, late mixed, or early permanent dentition who were examined clinically at the ages of 8 to 17 years and again 25 years later. The treated subgroup of 58 subjects had received orthodontic treatment with fixed or removable appliances or both.

A patient-administered Medical Risk Related History questionnaire (EMRRH) for use in 10 European countries (multicenter trial).

Objective: The objective of this study was to produce a standardized medical risk-related history (MRRH) in order to identify the medically compromised patient (MCP) attending the general dental practitioner for treatment, to develop such a history (EMRRH), and to validate it in dental practices in 10 European countries.

Study Design: The Dutch MRRH, adapted to allow for legal and cultural differences of the participating countries was introduced. After consensus and repeated testing, the questionnaire was validated.

Orthodontic treatment experience and prevalence of malocclusion traits in an Icelandic adult population.

Introduction: The objectives of this study were to record the extent of orthodontic treatment and the prevalence of occlusal anomalies in an adult sample in Iceland.

Methods: The study was based on a random sample of 829 subjects, 342 men and 487 women, aged 31 to 44 years, who completed questionnaires about their orthodontic treatment experiences and were available for clinical examination.

Results: Complete dentitions in both jaws were present in 52.

Dental anxiety in Iceland: an epidemiological postal survey.

In this study, we examined the prevalence of specific (dental) phobia among a sample of the Icelandic population. In addition to dental anxiety we explored factors that could be related to dental anxiety. In the period 1972-73, a stratified sample of 1641 schoolchildren in Reykjavík was selected for a study on malocclusion, dental maturation and other factors.