Associations between brake and tire wear-related PM metal components, particulate oxidative stress potential, and autism spectrum disorder in Southern California.

Background: Air pollution is a global health concern, with fine particulate matter (PM) constituents posing potential risks to human health, including children's neurodevelopment. Here we investigated associations between exposure during pregnancy and infancy to specific traffic-related PM components with Autism Spectrum Disorder (ASD) diagnosis.

Methods: For exposure assessment, we estimated PM components related to traffic exposure (Barium [Ba] as a marker of brake dust and Zinc [Zn] as a tire wear marker, Black Carbon [BC]) and oxidative stress potential (OSP) markers (Hydroxyl Radical [OP] formation, Dithiothreitol activity [OP], reactive oxygen species [ROS]) modeled with land use regression with co-kriging based on an intensive air monitoring campaign.

Sources of personal PM exposure during pregnancy in the MADRES cohort.

Background: Personal exposure to fine particulate matter (PM) is impacted by different sources each with different chemical composition. Determining these sources is important for reducing personal exposure and its health risks especially during pregnancy.

Objective: Identify main sources and their contributions to the personal PM exposure in 213 women in the 3rd trimester of pregnancy in Los Angeles, CA.

Effects of in-utero personal exposure to PM sources and components on birthweight.

In-utero exposure to fine particulate matter (PM) and specific sources and components of PM have been linked with lower birthweight. However, previous results have been mixed, likely due to heterogeneity in sources impacting PM and due to measurement error from using ambient data. Therefore, we investigated the effect of PM sources and their high-loading components on birthweight using data from 198 women in the 3rd trimester from the MADRES cohort 48-h personal PM exposure monitoring sub-study.

A Comparison of Measured Airborne and Self-Reported Secondhand Smoke Exposure in the MADRES Pregnancy Cohort Study.

Introduction: Secondhand smoke (SHS) exposure during pregnancy is linked to adverse birth outcomes, such as low birth weight and preterm birth. While questionnaires are commonly used to assess SHS exposure, their ability to capture true exposure can vary, making it difficult for researchers to harmonize SHS measures. This study aimed to compare self-reported SHS exposure with measurements of airborne SHS in personal samples of pregnant women.

Effects of In-Utero Personal Exposure to PM2.5 Sources and Components on Birthweight.

Background: In-utero exposure to fine particulate matter (PM) and specific sources and components of PM have been linked with lower birthweight. However, previous results have been mixed, likely due to heterogeneity in sources impacting PM and due to measurement error from using ambient data. Therefore, we investigated the effect of PM sources and their high-loading components on birthweight using data from 198 women in the 3 trimester from the MADRES cohort 48-hour personal PM exposure monitoring sub-study.

In-utero personal exposure to PM impacted by indoor and outdoor sources and birthweight in the MADRES cohort.

Background: In-utero exposure to outdoor particulate matter with aerodynamic diameter less than 2.5 μm (PM) is linked with low birthweight. However, previous results are mixed, likely due to measurement error introduced by estimating personal exposure from ambient data.

The impact of GPS-derived activity spaces on personal PM exposures in the MADRES cohort.

Background: In-utero exposure to particulate matter with aerodynamic diameter less than 2.5 μm (PM) is associated with low birth weight and health risks later in life. Pregnant women are mobile and locations they spend time in contribute to their personal PM exposures.