Publications by authors named "Karl Moles"
Article Synopsis
- Recent studies highlight that both excessive and insufficient nitric oxide (NO) production play key roles in heart failure with preserved ejection fraction (HFpEF), raising interest in NO-targeted therapies.
- A mouse model (using high-fat diets and specific treatments) was used to explore the effects of a dual-nitric oxide therapy (sodium nitrite and hydralazine) on heart function and stress levels related to HFpEF.
- The treatment notably improved NO availability and heart function, reduced oxidative stress, and enhanced exercise capacity, suggesting it may effectively mitigate the severity of HFpEF.
Background Hydrogen sulfide (HS) is an important endogenous physiological signaling molecule and exerts protective properties in the cardiovascular system. Cystathionine γ-lyase (CSE), 1 of 3 HS producing enzyme, is predominantly localized in the vascular endothelium. However, the regulation of CSE in vascular endothelium remains incompletely understood.
View Article and Find Full Text PDF