Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model.

Background: Cardiac magnetic resonance (MR) perfusion imaging during the first pass after intravenous administration of extracellular contrast agents is hampered by the spatial and temporal resolution achievable and by the artifacts seen in ultrafast MR imaging. Furthermore, time-consuming quantitative data analysis is often added. The use of molecular MR imaging with a target-specific contrast agent with perfusion-dependent binding to myocardium may enable prolonged visualization of perfusion defects and thus may help to overcome limitations of currently used first-pass extracellular MR imaging.

Time-resolved 3D MR angiography of the foot at 3 T in patients with peripheral arterial disease.

Objective: The objective of our study was to prove the feasibility and clinical relevance of fast contrast-enhanced time-resolved 3D MR angiography (MRA) with submillimeter spatial resolution at a high magnetic field strength.

Subjects And Methods: Twenty-one patients (five women, 16 men; mean age +/- SD, 65 +/- 14 years) were examined on a 3-T whole-body MR system with an 8-element phasedarray coil for preoperative evaluation of the pedal arterial system and assessment of the visualized vessels to serve as a graft touch-down site in pedal bypass surgery. Time-resolved 3D MRA of the foot was performed after automatic injection of 0.

Variability of aortic valve calcification measurement with multislice spiral computed tomography.

Objectives: We sought to assess the variability of aortic valve calcifications (AVCs) regarding the reconstruction window at different heart phases using multislice-spiral computed tomography.

Materials And Methods: A total of 46 patients (26 men; mean age. 65 years) underwent AVC scoring with multislice-spiral computed tomography (12 x 0.