Publications by authors named "Karl K Kuban"
Background Extremely preterm (EP) birth is associated with higher risks of perinatal white matter (WM) injury, potentially causing abnormal neurologic and neurocognitive outcomes. MRI biomarkers distinguishing individuals with and without neurologic disorder guide research on EP birth antecedents, clinical correlates, and prognoses. Purpose To compare multiparametric quantitative MRI (qMRI) parameters of EP-born adolescents with autism spectrum disorder, cerebral palsy, epilepsy, or cognitive impairment (ie, atypically developing) with those without (ie, neurotypically developing), characterizing sex-stratified brain development.
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- The study investigates the link between maternal education and neurocognitive as well as academic outcomes in children born extremely preterm (EP), specifically those born between 23 to 27 weeks of gestation.
- It finds that children whose mothers had lower education levels at birth performed significantly worse on cognitive tests, with many scoring below the expected range.
- Conversely, children whose mothers improved their education during the first 10 years showed a reduced risk of poor outcomes, suggesting a modest positive impact of educational advancement on neurocognitive development.*
Objective: To examine the predictive validity of the Modified Checklist for Autism in Toddlers (M-CHAT) administered at age 24 months for autism spectrum disorder (ASD) diagnosed at 10 years of age in a US cohort of 827 extremely low gestational age newborns (ELGANs) followed from birth.
Study Design: We examined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the M-CHAT in predicting an ASD diagnosis at age 10 years based on gold standard diagnostic instruments. We then assessed how these predictive parameters were affected by sensorimotor and cognitive impairments, socioeconomic status (SES), and emotional/behavioral dysregulation at age 2 years.