Publications by authors named "Karl J Fischer"
Article Synopsis
- Methicillin-resistant strains have become a major cause of complications and increased death rates in patients with influenza, as shown in a mouse model study.
- The study reveals that prior influenza infection leads to an increase in inflammatory monocytes in the lungs, which helps bacteria resist antibiotic treatment.
- Targeting CCR2, the receptor responsible for monocyte recruitment, with a small inhibitor alongside antibiotics improved bacterial clearance and survival rates in infected mice.
Article Synopsis
- * Researchers found that the failure of antibiotics is linked to oxidative stress-induced lung injury, which leads to the necrotic death of inflammatory cells and significant tissue damage, rather than just increased inflammation or cell count.
- * Combining antibiotics with an NADPH oxidase inhibitor showed improved survival rates in infected mice, suggesting that treatment strategies should address both the bacterial infection and the oxidative stress caused by the immune response for better patient outcomes.
Article Synopsis
- - The incidence of MRSA pneumonia is on the rise among healthy individuals, prompting research into why certain strains, particularly community-associated (CA)-MRSA, are so successful in spreading.
- - Using a mouse model, researchers found that CA-MRSA strains are more resistant to being cleared from the lungs than other strains associated with hospital infections, due to their ability to withstand innate immune responses.
- - The study reveals that CA-MRSA's survival isn't due to escaping immune cells like neutrophils but rather their resistance to intracellular killing by alveolar macrophages, and that this virulence is less crucial in hosts with existing conditions like influenza.
