Synthesis, Molecular Docking and Biological Evaluation of Iminostilbene Linked 1,2,3-Triazole Pharmacophores as Promising Anti- Anxiety and Anti-Inflammatory Agents.

Background: Iminostilbene and 1,2,3-triazole ring containing compounds are considered as beneficial substrates in drug design.

Objectives: This study was aimed at the synthesis of novel series of iminostilbene linked 1,2,3- triazole pharmacophores (7c-n) by Cu(I) catalyzed 1,3 dipolar cycloaddition reaction between 5- (Prop-2-yn-1-yl)-5H-dibenzo[b,f]azepine (7b) and various substituted azidobenzene derivatives (3cn).

Methods: The chemical structures of compounds were confirmed by H NMR, C NMR, LC-MS and molecular docking studies were carried out through HEX docking software.