Publications by authors named "Kariya Y"

Various tubular diseases in patients with multiple myeloma (MM) are caused by monoclonal immunoglobulin light chains (LCs). However, the physicochemical characteristics of the disease-causing LCs contributing to the onset of MM-associated tubular diseases remain unclear. We herein report a rare case of MM-associated combined tubulopathies: non-crystalline light chain proximal tubulopathy (LCPT) and crystalline light chain cast nephropathy (LCCN).

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  • Treating cryptococcosis in HIV patients is tough due to limited antifungal options and lack of approval for isavuconazole in the US and Europe.
  • A case study follows a Japanese man who developed cryptococcal meningitis, relapsed after fluconazole treatment, and was later diagnosed with disseminated cryptococcosis.
  • He was successfully treated with a combination of isavuconazole and liposomal amphotericin B, suggesting that isavuconazole may be a viable treatment option, warranting further clinical trials to ensure effectiveness and safety.*
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  • Biological systems are very complicated, and researchers work hard to understand them, but it can be tough to put all the information together.
  • Our study looks at how a specific protein (RANK) works with another protein (RANKL) in bone metabolism, showing that understanding them in different cells is challenging.
  • We suggest using mathematical models in two ways to help simplify and analyze these complex systems, which can help us learn more about how drugs affect biological processes.
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The use of mathematical models has become increasingly prevalent in pharmacological fields, particularly in drug development processes. These models are instrumental in tasks such as designing clinical trials and assessing factors like efficacy, toxicity, and clinical practice. Various types of models have been developed and documented.

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  • Human granulocytic anaplasmosis (HGA) is a rare tick-borne disease in Japan, with only seven reported cases, including a significant one involving a 61-year-old female farmer.
  • The patient presented with symptoms like rash, fever, and rhabdomyolysis, and testing revealed elevated levels of creatinine and creatinine kinase, indicating muscle damage, alongside a tick bite.
  • Despite initial treatments for suspected Japanese spotted fever, the diagnosis of HGA was confirmed through antibody detection, highlighting the need for better diagnostic systems and awareness of HGA in Japan, especially for patients with outdoor activity history.
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Drug resistance is a major obstacle to successful cancer treatment. Therefore, it is essential to understand the molecular mechanisms underlying drug resistance to develop successful therapeutic strategies. α6β4 integrin confers resistance to apoptosis and regulates the survival of cancer cells; however, it remains unclear whether α6β4 integrin is directly involved in chemoresistance.

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Various diseases (e.g., hypertension and diabetes) are risk factors for the exacerbation of coronavirus 2019 (COVID-19).

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This study investigated a novel method for artificial synthesis of β-tricalcium phosphate (β-TCP). The binder of the phosphate-bonded investment was replaced with calcium oxide instead of magnesium oxide and sintered in an electric furnace. The water/powder mixing ratio for hardening was determined using preliminary experiments.

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Objectives: To compare the findings of muscle magnetic resonance imaging (MRI) between anti-signal recognition particle antibody-positive myopathy (anti-SRP myopathy) and anti-aminoacyl-tRNA synthetase antibody-positive myositis (anti-ARS myositis).

Methods: Of the patients newly diagnosed with polymyositis (PM)/dermatomyositis (DM) and immune-mediated necrotising myopathy (IMNM) admitted to our Department between April 2012 and December 2021, those who met the eligibility criteria of positive for anti-SRP or anti-ARS antibodies and thigh MRI at the time of diagnosis were included. We compared the lesion sites and MRI findings of the thigh muscles that were classified into oedema, fascial oedema, fatty replacement, and muscle atrophy between the three groups of anti-SRP myopathy, anti-Jo-1 antibody-positive myositis, and non-Jo-1 antibody-positive myositis.

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This study aimed to develop a new and effective application form for the liver surface. We designed a two-layered sheet for the controlled release and local disposition of the anticancer drug, 5-fluorouracil (5-FU), without leakage into the peritoneal cavity. We employed poly(lactic-co-glycolic acid) (PLGA) and hydroxypropyl cellulose (HPC) to form two-layered sheets by attaching a cover sheet and a drug-containing sheet.

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Disulfide bonds of 2-isocyanatophenyl methyl disulfide and 2--isocyanato-6--(methyldisulfanyl)bicyclo[2.2.1]heptane showed neighboring group participation in the formation of thiocarbamates.

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Simulating complex biological models consisting of multiple ordinary differential equations can aid in the prediction of the pharmacological/biological responses; however, they are often hampered by the availability of reliable kinetic parameters. In the present study, we aimed to discover the properties of behaviors without determining an optimal combination of kinetic parameter values (parameter set). The key idea was to collect as many parameter sets as possible.

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Neuropsychiatric systemic lupus erythematosus (NPSLE) with cerebral vasculitis is rare, and its prognosis is unfavorable. High-dose glucocorticoids and cyclophosphamide are widely used for the treatment of NPSLE, but cyclophosphamide has a risk of cervical intraepithelial neoplasia and ovarian insufficiency, which may discourage its use in young women. We experienced a case of NPSLE with cerebral vasculitis and lupus nephritis that responded successfully to glucocorticoids and mycophenolate mofetil (MMF).

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  • The study focuses on assessing the clinical characteristics of rheumatoid arthritis (RA) patients with human T-cell leukaemia virus type 1 (HTLV-1) infection and its effects on serious infections and cancers.
  • A total of 150 HTLV-1-negative and 50 HTLV-1-positive RA patients were analyzed, revealing that those with HTLV-1 had higher patient-reported health assessments despite similar inflammatory markers.
  • The incidence rates of serious infections and malignancies were notably higher in HTLV-1-positive patients, suggesting that HTLV-1 infection may exacerbate RA symptoms and increase the risk of severe health issues.
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Osteopontin (OPN) plays a pivotal role in cancer cell invasion and metastasis. Although OPN has a large number of phosphorylation sites, the functional significance of OPN phosphorylation in cancer cell motility remains unclear. In this study, we attempted to investigate whether phosphorylated OPN secreted from cancer cells affect cancer cell migration.

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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tickborne infectious disease in China, Korea, and Japan caused by the SFTS virus (SFTSV). SFTS has a high mortality rate due to multiorgan failure. Recently, there are several reports on SFTS patients with mycosis.

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Epithelial-mesenchymal transition (EMT) plays a pivotal role for tumor progression. Recent studies have revealed the existence of distinct intermediate states in EMT (partial EMT); however, the mechanisms underlying partial EMT are not fully understood. Here, we demonstrate that αvβ3 integrin induces partial EMT, which is characterized by acquiring mesenchymal phenotypes while retaining epithelial markers.

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Objectives: Our previous study showed that the effectiveness of tumor necrosis factor (TNF) inhibitors was attenuated in anti-human T-cell leukemia virus type 1 (HTLV-1) antibody-positive patients with rheumatoid arthritis (RA). We aimed to evaluate the effectiveness and safety of non-TNF inhibitors in anti-HTLV-1 antibody-positive patients with RA.

Methods: We reviewed patients with RA who received abatacept or tocilizumab as the first biologic agent.

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α6β4 integrin plays pivotal roles in cancer progression in several types of cancers. Our previous study using N-glycan-manipulated cell lines demonstrated that defects in N-glycans or decreased β1,6GlcNAc-branched N-glycans on β4 integrin suppress β4 integrin-mediated cancer cell adhesion, migration, invasion, and tumorigenesis. Furthermore, immunohistochemical analysis has shown that colocalization of β1,6GlcNAc-branched N-glycans with β4 integrin was observed in cutaneous squamous cell carcinoma (SCC) tissue.

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Background: CD4-positive T cells are the main target of human T-cell leukemia virus type 1 (HTLV-1). Interferon-γ release assays rely on the fact that T-lymphocytes release this cytokine when exposed to tuberculosis-specific antigens and are useful in testing for latent tuberculosis infection before initiating biologic therapy, such as anti-tumor necrosis factor agents. However, the reliability of interferon-γ release assays in detecting tuberculosis infection among HTLV-1-positive patients with rheumatoid arthritis (RA) remains unclear.

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  • A 61-year-old woman with HTLV-1-associated myelopathy and interstitial pneumonia was admitted with symptoms like dry eyes, joint pain, and swelling.
  • She was diagnosed with rheumatoid arthritis and Sjögren's syndrome but could not take standard treatments due to her severe respiratory and neurological conditions.
  • Tocilizumab monotherapy was effective in reducing the rheumatoid arthritis activity without worsening her neurological symptoms, indicating its potential as a safe treatment option for similar patients.
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Aims: Dermatopathic reaction is a histopathological finding of lymph nodes that usually occurs in patients with inflammatory pruritic cutaneous lesions. However, it is sometimes seen in patients with cutaneous T cell lymphoma. Adult T cell leukaemia/lymphoma (ATLL) is a T cell malignancy caused by infection with human T cell leukaemia virus type I (HTLV-1), which is frequently accompanied by cutaneous lesions.

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  • A 3-month-old boy developed small papules on his trunk, prompting a diagnosis of Langerhans cell histiocytosis after pathological examination.
  • Initially, the papules were isolated to his skin with no organ involvement, classified as single-system, skin-limited LCH.
  • Treatment with topical steroids led to regression of the skin rashes, with all papules disappearing by 6 months, and involved understanding the role of genetic mutations, especially in the BRAF gene, contributing to the condition's development.
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Background: Acute encephalitis and encephalopathy are life-threatening diseases in children. However, no laboratory examinations are performed for their early diagnosis and treatment. Alpha 2-macroglobulin (α2M) is a blood glycoprotein that increases during the early stages of inflammation.

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An organism stems from assemblies of a variety of cells and proteins. This complex system serves as a unit, and it exhibits highly sophisticated functions in response to exogenous stimuli that change over time. The complete sequencing of the entire human genome has allowed researchers to address the enigmas of life and disease at the gene- or molecular-based level.

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