Publications by authors named "Karissa Yan"
Fly (Austin)
December 2024
Article Synopsis
- Mifepristone and rapamycin were tested for their ability to extend the life span of mated female subjects, with rapamycin showing an optimal concentration of 50 μM increasing life span by 81%, while mifepristone at 466 μM increased life span by 114%.
- Combining the two drugs did not enhance life span further and, in fact, decreased it relative to using either drug alone.
- Both drugs were effective at reducing mating-induced midgut hypertrophy and activated a mitophagy reporter, suggesting they may work through a similar mechanism to promote longevity by enhancing mitophagy and reducing midgut enlargement.
Article Synopsis
- Mating in female organisms leads to changes like enlarged midguts and shorter lifespans, but the drug mifepristone can prevent these changes.
- Eip75B, a crucial transcription factor, needs specialized techniques to study its effects on lifespan due to its lethal mutations.
- Using a FLP-recombinase system, researchers found that inhibiting Eip75B activity stops the negative effects of mating and mifepristone on females' midgut size, lifespan, and egg production.
