Publications by authors named "Karine Sejean"
Background: Pembrolizumab is approved for patients with metastatic urothelial carcinoma (UC) who progressed under platinum therapy. The aim of this study was to assess the efficacy and safety of pembrolizumab in a cohort of real-life UC patients.
Methods: This retrospective, observational study included advanced UC patients treated with pembrolizumab in a single institution in France.
In developed countries, most people living with HIV/AIDS are treated with costly brand single-tablet regimens. Given the economic impact, French guidelines recommend using generic antiretroviral therapy when possible to decrease antiretroviral therapy costs. We aimed to study HIV-infected patients' acceptability to switch from a brand single-tablet regimens [abacavir/lamivudine/dolutegravir (Triumeq®) or emtricitabine/tenofovir disoproxil fumarate/rilpivirine (Eviplera®)] to a treatment comprising of two pills: one is a fixed-dose generic combination of 2 Nucleoside Analogs and the second tablet is the third antiretroviral.
View Article and Find Full Text PDFArticle Synopsis
- - The outpatient oncology-monitoring program aims to improve patient care by reorganizing practices within clinical departments and enhancing monitoring through pre-chemotherapy patient calls conducted by specialized nurses.
- - In the first three months of implementation, the program involved 382 patients, achieving an 87% completion rate for clinical questionnaires and significantly improving early drug preparation rates from 0% to 40% for expensive drugs.
- - Preliminary results indicate high patient compliance and a decrease in wastage of chemotherapy preparations; however, further studies are needed to assess satisfaction and optimize operational efficiency in the long run.
Cancer patient dissatisfaction, due to a long waiting time for chemotherapy treatment, is a common complaint. To improve patient satisfaction, our pharmaceutical team was prompted to design a series of information tools for injectable chemotherapy drug treatment (ICDT) patients. This study was based on French Health Authorities recommendations.
View Article and Find Full Text PDFObjectives: To examine the cost-effectiveness of strategies for management of primary asymptomatic hyperparathyroidism: surgical strategies and medical follow-up versus surgery.
Design: We used a Markov state-transition decision-analytic model for an hypothetical cohort of 55-year-old women to compare with a lifetime horizon costs and effectiveness of bilateral neck exploration (BNE), unilateral neck exploration (UNE), video-assisted parathyroidectomy (VAP) and lifelong medical follow-up shifting for either BNE or UNE in case of disease progression.
Methods: Data on localization tests, complications and treatment efficacies were derived from a systematic review of the literature.