Publications by authors named "Karine R D Silveira"
Leishmania major is the causative agent of cutaneous leishmaniasis. It is one of the most studied Leishmania species not only during vector interaction but also in the vertebrate host. Lipophosphoglycan (LPG) is the Leishmania multifunctional virulence factor during host-parasite interaction, whose polymorphisms are involved in the immunopathology of leishmaniasis.
View Article and Find Full Text PDFVertical Transmission of Zika Virus (Flaviviridae, Flavivirus) in Amazonian Aedes aegypti (Diptera: Culicidae) Delays Egg Hatching and Larval Development of Progeny.
J Med Entomol
October 2019
Article Synopsis
- Zika virus (ZIKV) is primarily transmitted to humans by Aedes aegypti and Aedes albopictus mosquitoes, and research is exploring whether the virus can also be passed vertically from infected female mosquitoes to their offspring.
- A colony of ZIKV and dengue virus-free mosquitoes was established in Manaus for experiments, revealing that ZIKV can be vertically transmitted to the F1 progeny, which showed high susceptibility to infection (96.7%).
- The infected offspring exhibited lower egg hatch rates and slower development compared to controls, suggesting that ZIKV infection can significantly alter the life cycle of Aedes aegypti and may play a crucial role in the virus's spread and maintenance in nature.
Background: Zika disease has transformed into a serious global health problem due to the rapid spread of the arbovirus and alarming severity including congenital complications, microcephaly and Guillain-Barré syndrome. Zika virus (ZIKV) is primarily transmitted to humans through the bite of an infective mosquito, with Aedes aegypti being the main vector.
Methods: We successfully developed a ZIKV experimental transmission model by single infectious Ae.