Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice.

Objective: To evaluate the effects of oxidative stress on insulin signaling in cardiac tissue of obese mice.

Methods: Thirty Swiss mice were equally divided (n=10) into three groups: Control Group, Obese Group, and Obese Group Treated with N-acetylcysteine. After obesity and insulin resistance were established, the obese mice were treated with N-acetylcysteine at a dose of 50mg/kg daily for 15 days via oral gavage.