Publications by authors named "Karine Blais"
Article Synopsis
- Transcription factor HLH-30/TFEB regulates autophagy, and silencing the nuclear export protein XPO-1/XPO1 enhances autophagy by keeping HLH-30 in the nucleus.
- This increase in autophagy leads to advantages like better proteostasis and longer lifespan in C. elegans, requiring both HLH-30 and autophagy.
- The study suggests that inhibiting XPO1 can boost autophagy and potentially protect against neurodegeneration, indicating a conserved mechanism across different cell types.
Bombesin, a pan agonist of the bombesin-like peptide receptor family, elicits potent hypothermia when applied centrally. The signaling mechanisms involved are not known. Here we report that GABAergic preoptic neurons express gastrin-releasing peptide (GRP) receptors and are directly excited by GRP or bombesin.
View Article and Find Full Text PDFTransitin is a nestin-like intermediate filament protein co-expressed with vimentin in the precursor cells of the myogenic and neurogenic lineages of the avian embryo. To understand its role in myogenesis, stable cell lines expressing transitin-targeted siRNAs were derived from the quail muscle cell line QM7. When cells were cultured in differentiation medium, we found that transitin knockdown prevented myoblast fusion and myotube formation.
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