Publications by authors named "Karina Stringhetta-Padovani"
Background: Ischemic stroke produces a large health impact worldwide, with scarce therapeutic options.
Objective: This study aimed to reveal the role of NADPH oxidase and neuroinflammatory genes in the cerebral anti-ischemic effects of C-Phycocyanin (C-PC), the chief biliprotein of Spirulina platensis.
Methods: Rats with either focal cerebral ischemia/reperfusion (I/R) or acute brain hypoperfusion, received C-PC at different doses, or a vehicle, for up to 6 h post-stroke.
Article Synopsis
- HnRNP K protein is linked to the development of acute promyelocytic leukemia (APL) and its differentiation process when treated with all-trans retinoic acid (ATRA), showing significant mRNA levels in APL patients at diagnosis.
- The study explored the roles of hnRNP K and SET proteins in APL, finding that knocking down hnRNP K led to cell death and increased granulocytic differentiation, especially in ATRA-resistant cells.
- Combination treatments involving arsenic trioxide and an ERK inhibitor demonstrated enhanced effects against tumor growth, suggesting that targeting hnRNP K, SET, and related pathways could improve therapies for APL and drug-resistant cases.
As SET protein is overexpressed and PP2A activity is reduced in oral squamous cell carcinoma (OSCC), this study aimed to assess the effects induced by OP449, a PP2A activator/SET inhibitor, on OSCC cells in vitro, and its potential either isolated or combined with FTY720, a PP2A activator/sphingosine kinase 1 antagonist, as antitumoral therapy in vivo. SET protein was analyzed in cells by immunoblotting and cancer stem cells by aldehyde dehydrogenase 1 assay (ALDH1). The cytotoxicity of OP449 was determined in five OSCC lineages by resazurin assay.
View Article and Find Full Text PDFDuring perimenopause, oxidative stress increases, which may result in disruption of bone turnover, and consequently in osteoporosis. The use of antioxidants may be an effective nutritional approach to reducing osteoporosis in this period of life. Mate tea (MT) (Ilex paraguariensis), a typical and inexpensive beverage consumed in the Brazilian south-east, Argentina and Uruguay, increases antioxidant defense.
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