Publications by authors named "Karina Pacholczyk"
Article Synopsis
- Gastric adenocarcinoma (GCa) has a high fatality rate in Europe and North America, largely due to late-stage diagnoses, despite advancements in treatment options.
- There is significant interest in FAM46C, a protein linked to tumor suppression, as its depletion is commonly observed in GCa patients and is associated with cancer recurrence and mortality.
- Research is exploring FAM46C as a potential biomarker and therapeutic target for GCa progression, with Norcantharidin emerging as a promising compound to restore FAM46C levels currently in phase one clinical trials.
Proteostasis requires oxidative metabolism (ATP) and mitigation of the associated damage by glutathione, in an increasingly dysfunctional relationship with aging. SLC3A2 (4F2hc, CD98) plays a role as a disulfide-linked adaptor to the SLC7A5 and SLC7A11 exchangers which import essential amino acids and cystine while exporting Gln and Glu, respectively. The positions of N-glycosylation sites on SLC3A2 have evolved with the emergence of primates, presumably in synchrony with metabolism.
View Article and Find Full Text PDFCaveolin-1 is a transmembrane protein with both tumor promoter and suppressor functions that remain poorly understood. Cav1 phosphorylation by Src kinase on tyrosine 14 is closely associated with focal adhesion dynamics and tumor cell migration, however the role of pCav1 in tumor progression remains poorly characterized. Herein, we expressed phosphomimetic Y14D, wild type, and non-phosphorylatable Y14F forms of Cav1 in MDA-MB-435 cancer cells.
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