Effects of intra-articular injection of platelet-rich plasma on the inflammatory process and histopathological characteristics of cartilage and synovium in animals with osteoarthritis: a systematic review with meta-analysis.

Background: Osteoarthritis (OA) affects the entire joint, causing structural changes in articular cartilage, subchondral bone, ligaments, capsule, synovial membrane, and periarticular muscles that afflicts millions of people globally, leading to persistent pain and diminished quality of life. The intra-articular use of platelet-rich plasma (PRP) is gaining recognition as a secure therapeutic approach due to its potential regenerative capabilities. However, there is controversial clinical data regarding efficacy of PRP for OA treatment.

Titanium Dioxide Nanoparticle (TiO NP) Induces Toxic Effects on LA-9 Mouse Fibroblast Cell Line.

Background/aims: Titanium dioxide nanoparticles (TiO NPs) are extensively applied in the industry due to their photocatalytic potential, low cost, and considerably low toxicity. However, new unrelated physicochemical properties and the wide use of nanoparticles brought concern about their toxic effects. Thereby, we evaluated the cytotoxicity of a TiO NP composed of anatase and functionalized with sodium carboxylate ligands in a murine fibroblast cell line (LA-9).

Associated with Acetylsalicylic Acid and Their Relation to the Hepatic Fibrosis in Infected Mice.

Schistosomiasis is an important parasitic disease caused by , an intravascular trematode. Schistosomiasis treatment is limited to just one drug, Praziquantel (PZQ). Thus, studies on new antischistosomal compounds are of fundamental importance to disease control.