Publications by Karina Giacomini Varela

Publications by authors named "Karina Giacomini Varela"

Br J Pharmacol

April 2024

Chemotherapy-induced peripheral neuropathy (CIPN) affects a significant percentage of patients receiving paclitaxel, leading researchers to explore TZD-A1, a new potential treatment.
The study involved various analyses to assess TZD-A1's interaction with PPARγ, its safety, and its effects on CIPN in mice, revealing a positive safety profile and effective reduction of neuropathy symptoms.
Results suggest that TZD-A1 mitigates the negative effects of paclitaxel by preventing neuroinflammation and mitochondrial damage, making it a promising candidate for enhancing the quality of life in cancer patients.

Toxicol Ind Health

November 2023

Manganese is a common element that's important for biological functions, but long-term exposure can lead to Manganism, a disorder similar to Parkinson's disease caused by mitochondrial issues and oxidative stress.
This study explored the neuroprotective effects of probucol, a compound known for its anti-inflammatory and antioxidant properties, on brain slices from rats exposed to manganese chloride.
Results showed that probucol effectively prevented manganese toxicity, maintaining cell viability and protecting mitochondrial function in the brain regions tested, highlighting its potential as an antioxidant therapy.

Neurotox Res

February 2022

Manganese is an essential metal for bodily functions, but excessive amounts can lead to neurotoxicity and a condition similar to Parkinson's known as manganism.
This study explored the protective effects of probucol, an anti-inflammatory and antioxidant lipid-lowering agent, against manganese-induced toxicity in human neuroblastoma (SH-SY5Y) and glioblastoma (C6) cell lines.
Results showed that while higher concentrations of manganese reduced cell viability, probucol effectively countered these effects by preventing mitochondrial dysfunction and lowering harmful reactive oxygen species (ROS) levels.

Regul Toxicol Pharmacol

June 2019

Manganese (Mn) is essential for biological functions but becomes toxic when accumulated excessively, particularly impacting the central nervous system (CNS), with limited research on its effects in other tissues.
This study examined how Mn exposure affects oxidative stress, metabolism, and Mn levels in peripheral organs of male and female Wistar rats, using various doses over a month-long period.
The findings indicated that while Mn concentrations increased in organs (especially kidneys), there were significant sex-related differences in toxic effects, with males showing greater oxidative stress and altered metabolic responses compared to females, despite similar levels of Mn deposition.