Publications by authors named "Karin Wilson"
Article Synopsis
- Autism spectrum disorder (ASD) includes a range of neurodevelopmental conditions with core behavioral symptoms critical for diagnosis, linked to altered dopamine (DA) neurotransmission in the striatum.
- Research in a mouse model with elevated eukaryotic initiation factor 4E (eIF4E) expression shows that this increase leads to behavioral inflexibility and impaired DA release in the striatum.
- These impairments stem from defective nicotinic receptor signaling affecting calcium dynamics in dopaminergic axons, highlighting the complex interactions between eIF4E, DA neurotransmission, and ASD symptoms, which could guide future therapies.
