Relative Deficiency of Anti-Inflammatory -Acylethanolamines Compared to Prostaglandins in Oral Lichen Planus.

Oral lichen planus (OLP) is a chronic inflammatory oromucosal disease. The -acylethanolamines (NAEs), are a family of endogenous biologically active lipid mediators, with palmitoylethanolamide (PEA) being of particular interest here due to its anti-inflammatory and analgesic properties. In this study using oral mucosa biopsies from OLP patients and healthy controls, we investigated whether NAE synthesis was mobilized in response to the inflammation associated with OLP.