[Risk factors for adverse drug reactions in patients admitted to intensive care units].

Background: Patients hospitalized in intensive care units (ICU) are at higher risk of having adverse drug reactions (ADR).

Aim: To determine risk factors for ADR, through intensive pharmacological surveillance at the ICU.

Patients And Methods: An observational, descriptive and prospective study was made, determining risk parameters in patients who experienced ADR.

Correction: Novel site-specific PEGylated L-asparaginase.

[This corrects the article DOI: 10.1371/journal.pone.

Novel site-specific PEGylated L-asparaginase.

L-asparaginase (ASNase) from Escherichia coli is currently used in some countries in its PEGylated form (ONCASPAR, pegaspargase) to treat acute lymphoblastic leukemia (ALL). PEGylation refers to the covalent attachment of poly(ethylene) glycol to the protein drug and it not only reduces the immune system activation but also decreases degradation by plasmatic proteases. However, pegaspargase is randomly PEGylated and, consequently, with a high degree of polydispersity in its final formulation.