Publications by authors named "Karin Mossberg"
Article Synopsis
- The study investigated how self-reported eating behaviors impact weight changes over 24 months in adults with severe obesity, involving 971 participants (75% women) with a mean BMI of 42.0 kg/m².
- The results showed that those who engaged in nocturnal eating lost less weight compared to those who did not, while binge eating disorder did not significantly affect weight loss over this period.
- Emotional eating was linked to less weight loss at 12 months and was a factor in participants dropping out of medical treatment, highlighting the importance of addressing harmful eating behaviors in obesity treatment.
Article Synopsis
- Persons with obesity undergoing bariatric surgery are at risk for nutritional deficiencies, particularly vitamin D, prompting this study to assess vitamin D levels post-surgery compared to those on a very low-energy diet (VLED).
- The study involved 971 participants, with measurements of vitamin D and calcium levels taken before and two years after treatment, showing that baseline vitamin D deficiency was more prevalent in individuals with obesity than in the general population.
- Results indicated that vitamin D levels generally improved for all treatment groups post-intervention, with only a small percentage experiencing deficiency afterward, suggesting that bariatric surgery, combined with vitamin D supplementation, does not significantly increase vitamin D deficiency risk compared to medical treatments.
Article Synopsis
- - The study compared the long-term effects on oral health between bariatric surgery and medical treatment for obesity in 66 Swedish females, focusing on dental caries over a 2-year period post-treatment.
- - Surgically treated patients experienced a significant increase in different types of dental caries, while medically treated patients did not show this increase; the most notable differences were in enamel and total caries.
- - The findings underscore the need for enhanced dental care and preventive measures for individuals undergoing surgical obesity treatments to address the observed rise in dental issues.
Changes in physical and mental health in Swedish schoolchildren in the digital age.
Acta Paediatr
October 2023
Article Synopsis
- The study aimed to examine changes in the physical and mental health of Swedish children in fourth and ninth grades between 2011 and 2020.
- It utilized a questionnaire for 196 students in 2020 and 254 in 2011, revealing significant increases in sleeping issues, tiredness, and dissatisfaction among fourth graders, along with a notable rise in school refusal.
- The findings suggest a correlation between increased digital habits and the worsening health symptoms in younger students, with ninth graders also maintaining high levels of physical and mental health issues.
Article Synopsis
- The study investigates the link between micronutrient deficiencies and anaemia in patients two years after bariatric surgery, focusing on those using supplementation versus those who are not.
- Conducted with 971 obese individuals in Sweden, it analyzes data from three surgical treatments (RYGB, SG, and MT) using blood samples and self-reported supplement use.
- Results show an increase in anaemia post-surgery, particularly with RYGB, suggesting that current guidelines on iron supplementation may not effectively prevent deficiencies, emphasizing the need for better preoperative nutrient management.
Article Synopsis
- Obesity negatively affects health-related quality of life (HRQoL), leading individuals to report lower overall well-being compared to the general population.
- In a study involving 1,122 participants with obesity and a control group of 414 individuals, lower scores in physical and mental health aspects were noted among those with obesity.
- The findings suggest a higher prevalence of mental health issues and medication use among obese individuals seeking treatment, highlighting their greater struggle with both physical and mental well-being.
Article Synopsis
- Plasminogen Activator Inhibitor-1 (PAI-1) inhibits the action of tissue-type Plasminogen Activator (t-PA), increasing the risk of cardiovascular events, especially in individuals with type 2 diabetes (T2D) and obesity.
- A study compared PAI-1 levels and mRNA expression in platelets from T2D, obese, and lean subjects to understand the contribution of platelets to elevated PAI-1 in T2D.
- Results showed no significant differences in PAI-1 levels in platelets among the groups, but elevated plasma PAI-1 was found in both T2D and obese subjects, suggesting other factors may contribute to high plasma
Article Synopsis
- The study aimed to investigate the relationship between obesity and oral health among young Swedish women, specifically analyzing how varying degrees of obesity affect dental conditions.
- The research involved 118 individuals with morbid obesity, using BMI categories to assess dental caries, periodontal health, and saliva analysis through clinical examinations and questionnaires.
- Results revealed that higher BMI correlated with increased instances of dental caries and poor oral hygiene, indicating a need for tailored dental care and prevention strategies for obese individuals.
Article Synopsis
- The study assessed how common and severe dry mouth (xerostomia) is among patients over 18 in western Sweden, focusing on variables like age, gender, illness, and medication use.
- Among 374 participants, 43.6% reported experiencing dry mouth, with a higher prevalence in females (61.2%) and a strong correlation to the number of medications taken.
- The findings emphasize that xerostomia is a significant issue in primary care that requires more attention from both medical and dental professionals, especially for patients on multiple medications.
Article Synopsis
- - The study compared long-term effects of medical treatment (MT) versus bariatric surgery (specifically Roux-en-Y gastric bypass and sleeve gastrectomy) in individuals with obesity, focusing on weight loss and safety outcomes over two years.
- - Out of 971 participants, the surgical options (RYGB and SG) resulted in significantly greater weight loss compared to the medical treatment group, with success rates being higher in the surgical groups.
- - Overall, while bariatric surgery was found to be more effective for weight loss, MT also showed positive results, indicating that both approaches can benefit individuals in managing obesity.
Article Synopsis
- The study explores how a mix of biological and environmental factors contributes to obesity, using machine learning to analyze over 100 clinical variables affecting BMI.
- Conducted in Sweden with 971 participants undergoing obesity treatment, the research gathered data on demographics, BMI, health metrics, and lifestyle habits through questionnaires.
- The top predictors for BMI were found to be inspired by demographics and socioeconomic status, with lifestyle-related factors and certain biomarkers also playing significant roles.
Article Synopsis
- In obesity, free fatty acids (FFA) are traditionally linked to insulin resistance and high blood sugar, but hyperinsulinemia can also occur in individuals with normal blood sugar levels, prompting a reexamination of this relationship.
- Two studies were conducted: MD-Lipolysis analyzed how obesity affects insulin resistance through metabolic factors, and POEM confirmed differences in metabolites related to insulin resistance and body fat.
- Findings show that in insulin-resistant obese individuals with normal blood sugar, high FFA levels correlate with increased fat mass rather than insulin resistance, suggesting hyperinsulinemia may be a response to higher fat and FFA levels rather than a direct cause of insulin issues.
Article Synopsis
- The study aims to profile the oral health of individuals who have undergone gastric bypass or sleeve gastrectomy surgeries to propose future research topics.
- A group of 14 patients, aged 31 to 66 with a BMI over 25, showed significant oral health issues, including severe decay and low saliva production, with only four being fully dentate.
- Results indicate that these patients experienced poor oral hygiene and multiple related problems, highlighting the need for long-term monitoring of oral health in bariatric surgery patients.
Article Synopsis
- BASUN is a long-term study examining the effects of surgical and medical weight-loss treatments for obesity over 10 years, focusing on areas like nutritional deficiencies and mental health.
- The study involved 1,127 participants with a BMI of 35 or higher, who could choose between Roux-en-Y gastric bypass, sleeve gastrectomy, or a structured medical treatment plan, with evaluations scheduled at multiple points.
- With a final group of 971 subjects, this research aims to provide valuable insights into long-term treatment outcomes that are often overlooked in shorter studies.
Article Synopsis
- Obesity and type 2 diabetes (T2D) increase plasma levels of plasminogen activator inhibitor 1 (PAI-1), which can suppress fibrinolysis and raise the risk of blood clots.
- A study examined PAI-1 levels in 12 obese patients (with and without T2D) before and after gastric bypass surgery to understand how changes in body fat and weight loss affect these levels.
- Results showed a significant decrease in PAI-1 levels shortly after surgery, particularly in non-T2D patients, while T2D patients exhibited an increase in PAI-1 levels later on, highlighting the need for further research on the factors influencing PAI-1 synthesis.
Article Synopsis
- - Human platelets contain mRNA and microRNA, which play roles in protein translation and regulation; however, stable reference genes for gene expression studies in platelets have not been thoroughly evaluated.
- - This study aimed to identify stable mRNA transcripts for qPCR normalization in platelets, revealing that genes YWHAE, B2M, and PF4V1 showed consistent expression over time and across different conditions.
- - The analysis indicated that YWHAE emerged as the most stable gene among healthy donors, and its stability was further supported when examining the impact of miRNA via Dicer1 knockdown in a cell line.