Publications by authors named "Karin Levy-Schousboe"
No Detectable Coagulation Activation After Vitamin K (MK-7) Supplementation in Patients on Dialysis With Functional Vitamin K Deficiency: A One-Year Randomized, Placebo-Controlled Study.
Else-Marie Bladbjerg Karin Levy-Schousboe Marie Frimodt-Møller Krista D Kjærgaard Charlotte Strandhave
J Ren Nutr
July 2024
Objective: Patients on dialysis treatment have poor functional vitamin K status, and this may increase the risk of vascular calcification. Vitamin K supplementation may therefore be relevant in patients on dialysis, but the procoagulant effects have not been studied. We evaluated effects of menaquinone-7 (MK-7) supplementation on biomarkers of coagulation in patients on dialysis.
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- Vitamin K deficiency is common in dialysis patients and may lead to lower bone mineral density (BMD) and higher fracture risk, prompting a study on the effects of menaquinone-7 (MK-7) supplementation.
- In a 2-year, double-blind trial with 123 chronic dialysis patients, participants received either MK-7 (360 µg) or a placebo while their BMD was assessed.
- Results showed that MK-7 supplementation led to accelerated BMD loss in the distal radius but prevented lumbar spine BMD decline, suggesting MK-7 affects BMD differently at various skeletal sites and does not support its use to protect bone health in dialysis patients.
Background: Arterial calcification is associated with cardiovascular mortality in dialysis patients. Active matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of arterial calcification. Elevated plasma concentrations of inactive MGP, i.
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