Publications by authors named "Karin Imaizumi"

Purpose: The association between maternal physique and prevalence of lactational mastitis (LM) in a large study population has not been reported. In this study, we aimed to evaluate the association between pre-pregnancy body mass index (BMI) and LM prevalence.

Methods: We analyzed data collected from participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study conducted between 2011 and 2014.

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  • The study investigated the link between atopic dermatitis in pregnant women and the risk of preterm births, focusing on those treated with ritodrine hydrochloride.
  • Data from over 83,000 women with singleton pregnancies were analyzed, using self-reported questionnaires to define atopic dermatitis and multivariable logistic regression to assess preterm birth risks.
  • Results showed that pregnant women with atopic dermatitis had lower odds of preterm birth before 37 weeks, indicating that atopic dermatitis might be associated with a decreased risk of preterm deliveries.
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  • The study investigates the link between breakfast habits during pregnancy and neurodevelopment in children, involving data from over 72,000 women in Japan.
  • Results indicate that regular breakfast consumption is associated with better communication skills in children at age 3, particularly benefiting those in specific maternal daily energy intake groups.
  • The findings suggest that maternal daily energy intake and the sex of the child can influence this association.
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  • - The study aimed to explore the link between high levels of urinary 8-hydroxy-2'-deoxyguanosine (U8-OHdG), a marker of oxidative stress, and the risk of preterm births (PTBs) in pregnant women.
  • - Conducted as a prospective cohort study with data from over 92,000 women in Japan, the research categorized U8-OHdG levels into different groups and analyzed their association with PTB incidence.
  • - Findings indicated that higher U8-OHdG levels were linked to an increased likelihood of PTBs, suggesting that oxidative stress may play a role in the occurrence of early births, particularly when excluding known causes of artificially induced PTBs.
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Objectives: No study has examined the effects of new constipation treatment drugs released in recent years in pregnant women. This prospective cohort study aimed to examine and compare the perinatal prognosis, efficacy rate, and safety of drugs frequently used to treat constipation.

Methods: The study included 211 perinatally managed individuals who answered a self-administered questionnaire during the second trimester and after delivery.

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  • - The study analyzed the link between maternal intimate partner violence (IPV) before and during pregnancy and the development of autism spectrum disorder (ASD) in their 3-year-old children, using data from the Japan Environment and Children's Study.
  • - It found that among nearly 80,000 offspring, 0.45% were diagnosed with ASD, with higher rates of physical IPV reported before conception compared to during pregnancy; specifically, physical IPV prior to conception was significantly associated with an increased risk of ASD.
  • - The research highlights the importance of preventive care against physical IPV before pregnancy to support neurodevelopment in children, while indicating that psychological IPV does not show the same association with ASD development in the offspring.
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  • The study examined the link between nonreassuring fetal status (NRFS) during labor and long-term neurodevelopmental delays in children using data from nearly 73,000 women in Japan.
  • Adjusted odds ratios indicated that NRFS was associated with personal-social issues in 3-year-olds, particularly for those born vaginally or via cesarean.
  • However, this association did not hold for infants with better neonatal outcomes, suggesting that factors like delivery method and neonatal health may influence the relationship between NRFS and neurodevelopmental delays.
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  • The study aimed to analyze the differences in maternal characteristics and childhood outcomes between term and post-term births (after 37 weeks) regarding the use of tocolytic treatment.
  • Data from 63,409 women in Japan was examined, revealing variations in maternal and obstetric outcomes between those who received tocolytic treatment and those who did not, but no significant differences in childhood developmental disorders.
  • It was found that tocolytic treatment was linked to higher rates of offspring allergies, with an adjusted odds ratio of 1.08, indicating a slight increase in allergic conditions among children from treated mothers.
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The incidence of Acinetobacter infections has increased in recent years. Acinetobacter infections are resistant to most antibiotics and can be found in hospitalized patients. Pregnancies complicated by severe sepsis or septic shock are associated with a higher rate of preterm labor and delivery, fetal infection, and operative delivery.

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  • A nationwide study in Japan analyzed data from 94,236 women with singleton births to evaluate the relationship between the timing of diagnosis for threatened preterm birth (TPTB) and the likelihood of preterm birth (PTB).
  • The research categorized women by gestational age at TPTB diagnosis and parity, using logistic regression models to calculate the odds of PTB occurring before 37 and 34 weeks.
  • Results indicated that the timing of TPTB diagnosis impacts PTB rates, with varying outcomes for nulliparous and multiparous women, highlighting the need for further research with comprehensive clinical data.
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We evaluated the association between maternal prenatal folic acid supplement use/dietary folate intake and cognitive development in 4-year-old offspring (N = 3445) using data from the Japan Environment and Children's Study. Cognitive development was evaluated using the Kyoto Scale of Psychological Development 2001. Multiple regression analysis revealed that offspring of mothers who started using folic acid supplements pre-conception had a significantly higher language-social developmental quotient (DQ) (partial regression coefficient 1.

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  • This study explored the relationship between maternal magnesium intake (MMI) and the occurrence of wheezing in 3-year-old children, hypothesizing that higher magnesium could reduce wheezing due to its anti-inflammatory properties.
  • Data from 79,907 pregnant women in Japan were analyzed, categorizing MMI into various levels to assess its impact on wheezing incidence in children.
  • The results indicated that higher MMI was slightly associated with an increased occurrence of childhood wheezing, suggesting that MMI might not significantly affect wheezing rates, and highlighting the need for further research on prenatal factors influencing childhood wheezing.
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The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early infancy on food allergy. However, the effects of exposure to pets other than dogs on the kinds of food allergies remains unaddressed. This study aimed to explore the effect of exposure to various species of pets on the risk of food allergies.

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This study evaluated the association between labour duration (LD) and incidence of low neonatal Apgar scores and foetal acidosis. Data of 37,682 women with full-term singleton spontaneous vaginal deliveries from the Japan Environment and Children's Study were analysed. Women were classified according to the median LD as nulliparous (< 10 or ≥ 10 h) or multiparous (< 5 or ≥ 5 h) and further into five subcategories: nulliparous (< 10.

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Aim: Hypertensive disorders of pregnancy (HDP) are a crucial cause of morbidity and mortality. We aimed to examine whether preconception carbohydrate intake is associated with new-onset HDP and small for gestational age (SGA) births.

Methods: We identified 93 265 normotensive (primiparous, 37 387; multiparous, 55 878) participants from the Japan Environmental Children's Study database who delivered between 2011 and 2014.

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We aimed to examine the impact of a preconception pro-inflammatory diet on gestational diabetes mellitus (GDM) using singleton pregnancy data from the Japan Environment and Children’s Study involving live births from 2011 to 2014. Individual meal patterns before pregnancy were used to calculate the dietary inflammatory index (DII). Participants were categorized according to DII quartiles 1−4 (Q1 and Q4 had the most pro-inflammatory and anti-inflammatory diets, respectively).

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Unlabelled: We aimed to evaluate the association between meconium-stained amniotic fluid during labor and offspring's childhood wheezing. This study analyzed the data of participants enrolled in the Japan Environment and Children's Study, a nationwide prospective birth cohort study, between 2011 and 2014. Data of women with singleton live births between 22 and 40 weeks' gestation were analyzed.

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Maternal prenatal psychological distress, which includes depression and anxiety, affects the onset of autism spectrum disorder (ASD). However, there is no consistent knowledge regarding at which term during pregnancy psychological distress affects the risk of ASD among children. We used a dataset obtained from the Japan Environment and Children's Study, which is a nationwide prospective birth cohort study, to evaluate the association between the six-item Kessler Psychological Distress Scale (K6) and ASD among 3-year-old children.

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Background: In reproductive medicine, vitamin D (VitD) is of particular interest because its deficiency has been linked to various infertility issues. Thus, preconception care, including appropriate VitD supplementation, is essential, especially in women using assisted reproductive technology (ART). Despite the therapeutic benefits of VitD, adverse events due to a high daily intake may influence obstetric outcomes.

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Background: While breastfeeding provides benefits for infants and the mother, many women either do not breastfeed or terminate breastfeeding earlier than recommended. The aim of this analysis was to identify factors associated with early discontinuation of breastfeeding in Japanese women.

Methods: This study used data from medical records of women delivering a singleton live birth between March 2017 and August 2019 in Iwase General Hospital, Fukushima Prefecture, Japan to assess cessation of breastfeeding by the 1-month postpartum appointment.

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This is the fourth reported case of central diabetes insipidus with oligohydramnios. Central diabetes insipidus does not adversely affect pregnancy; it can present with oligohydramnios, which can be improved by treating central diabetes insipidus.

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We describe two cases of spontaneously perforated pyometra (SPP) in elderly women treated with two different surgical approaches. An 88-year-old woman underwent emergency laparotomy for presumed diagnosis of gastrointestinal (GI) tract perforation. During surgery, SPP and a tumor of the sigmoid colon were identified.

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  • A 41-year-old woman experienced abdominal pain and was diagnosed with a large ovarian tumor, which turned out to be a rare borderline tumor from an extragonadal giant endometrial cyst.
  • Imaging revealed a 27 cm × 9 cm cystic tumor, which was surgically removed laparoscopically without involvement of the ovaries.
  • Post-surgery analysis showed it was an endometrioid borderline tumor linked to endometriosis, and a staging laparotomy confirmed no remaining tumor, highlighting the rarity of this case.
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