Randomized, double-blind, placebo-controlled trial of vaginal misoprostol for management of early pregnancy failures.

Objective: To determine whether misoprostol medical management of early pregnancy failures is more effective than expectant management.

Study Design: Patients diagnosed with early pregnancy failures, closed cervix, and minimal vaginal bleeding were randomized to 800 microg of misoprostol or placebo placed vaginally. Patients were evaluated by ultrasound imaging 24 hours and 48 hours after study drug administration, with repeat administration if 24-hour imaging showed a persistent gestational sac.