Publications by authors named "Karin Chersi"
Sporadic Hidradenitis Suppurativa (spHS) is a multifactorial disease in which genetic predisposition is intertwined with environmental factors. Due to the still to date limited knowledge of spHS genetics, we calculated Polygenic scores (PGS) to study the genetic underpinnings that contribute to spHS within European demographic. 256 spHS patients and 1686 healthy controls were analyzed across 6 European clinical centers.
View Article and Find Full Text PDFIntroduction: Patients with psoriasis who have failed multiple biologic drugs have been defined as "multi-failure," although there are no clear data on the characteristics, comorbidities, and best treatment strategies for this population. Nowadays, given the next generation and the number of biologics available, patients are considered multi-failure when ≥4 biologics fail to achieve a good response.
Methods: Demographic characteristics and efficacy of anti-interleukin drugs in multi-failure patients were compared to a cohort of general psoriatic patients treated with IL-23 or IL-17 inhibitors.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent around 40% of total HS cases and show an autosomal dominant mode of inheritance of the disease. In this study, we conducted a whole-exome sequence analysis on an Italian family of 4 members encompassing a vertical transmission of HS.
View Article and Find Full Text PDFArticle Synopsis
- Long-term management of psoriasis is crucial but challenging; the PSO-LONG trial showed that a combination treatment of betamethasone dipropionate and calcipotriol foam, applied twice a week for a year, can reduce relapses but still needs further investigation for long-term use.
- In the ProActive Management (PAM) program, experts reached consensus on 14 out of 18 statements, recognizing the importance of proactive topical treatments to minimize relapse risk, especially for resistant disease sites or when other therapies are not suitable.
- Establishing proactive strategies in treatment guidelines is seen as vital for improving the management of mild to moderate psoriasis, while more research on patient adherence is necessary.
Borreliae are divided into three groups, namely the Lyme group (LG), the Echidna-Reptile group (REPG) and the Relapsing Fever group (RFG). Currently, only Borrelia of the Lyme and RF groups (not all) cause infection in humans. Borreliae of the Echidna-Reptile group represent a new monophyletic group of spirochaetes, which infect amphibians and reptiles.
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