Modulation of the Acute Inflammatory Response Induced by the Lipopolysaccharide through the Interaction of Pentoxifylline and Florfenicol in a Rabbit Model.

Background: Experimental reports have demonstrated that florfenicol (FFC) exerts potent anti-inflammatory effects, improving survival in a murine endotoxemia model. Considering the anti-inflammatory and immunomodulatory properties of pentoxifylline (PTX) as an adjuvant to enhance the efficacy of antibiotics, the anti-inflammatory effects of the interaction FFC/PTX over the Lipopolysaccharide (LPS)-induced acute inflammatory response was evaluated in rabbits.

Methods: Twenty-five clinically healthy New Zealand rabbits (3.

Plasma disposition of florfenicol after intramuscular administration in rabbits pretreated with pentoxifylline.

This work aimed to assess the effects of the coadministration of pentoxifylline (PTX) on the pharmacokinetic profile of florfenicol (FFC) after intramuscular administration in rabbits. Ten New Zealand white rabbits, 1 year of age and 3.9 ± 0.