Modifications of Golgi complex in chondrocytes from osteoarthrotic (OA) rat cartilage.

The status of the Golgi complex in normal vs osteoarthrotic (OA) cartilage has not yet been studied. A monoclonal antibody, MAb 58-K-9, allowed scoring of Golgi labeling intensity. In addition, ultrastructural assessment enabled us to focus on the distribution and relation between the endoplasmic reticulum (ER) and Golgi membranes.

Kinetics of the ultrastructural changes in apoptotic chondrocytes from an osteoarthrosis rat model: a window of comparison to the cellular mechanism of apoptosis in human chondrocytes.

It is conceivable that apoptosis plays a relevant role in the pathogenesis of osteoarthrosis. We have dissected certain ultrastructural changes in apoptosis when comparing chondrocytes from the rat osteoarthrosis-induced model to those of human osteoarthrosis. Chondrocytes displayed a typical ultrastructural pattern prevailing according to the days following osteoarthrosis induction.