Publications by authors named "Karimatu Khoirunnisa"
Article Synopsis
- Dengue is a viral infection transmitted by mosquitoes, and its incidence is rising in Indonesia, making early detection crucial for outbreak control.
- In response, researchers developed in-house real-time PCR assays (TaqMan and SYBR types) to accurately diagnose dengue, with TaqMan showing the highest sensitivity.
- A study involving 74 suspected dengue patients demonstrated that while the NS1 rapid test had high specificity, it and other rapid tests alone are inadequate for definitive diagnosis, supporting the need for more sensitive molecular tests like TaqMan PCR.
Int J Infect Dis
September 2022
Article Synopsis
- The study aimed to compare gene expression and bacterial coinfection profiles in asymptomatic and mildly symptomatic COVID-19 patients using RNA sequencing of nasal swabs.*
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- Results showed that asymptomatic patients experienced changes in macroautophagy and cell cycle processes, while mildly symptomatic patients had modifications in RNA transport and upregulation of certain genes, though no link between the severity of disease and viral variants was established.*
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- The findings suggest that issues in autophagy and RNA processing could affect disease progression, highlighting the importance of considering bacterial coinfections like Streptococcus pneumoniae in symptomatic patients.*
