Evaluation of carbapenem antimicrobial stewardship program at a tertiary care hospital: A prospective interventional study.

This study aimed to determine physicians' acceptance rate of the Antimicrobial Stewardship Program ASP interventions in critically ill patients and to compare the clinical outcomes between accepted and rejected ASP groups. The study included patients on carbapenem therapy who were advised ASP interventions between 18-75 years of age and admitted in ICU/HDU from December 2020 to May 2021 at Liaquat National Hospital Karachi. Based on acceptance by the primary physician, data is divided into two groups.

Stroke radiology and distinguishing characteristics of intracranial atherosclerotic disease in native South Asian Pakistanis.

Background: There are no descriptions of stroke mechanisms from intracranial atherosclerotic disease in native South Asian Pakistanis.

Methods: Men and women aged ≥ 18 years with acute stroke presenting to four tertiary care hospitals in Karachi, Pakistan were screened using magnetic resonance angiography/transcranial Doppler scans. Trial of ORG 10172 in Acute Stroke Treatment criteria were applied to identify strokes from intracranial atherosclerotic disease.

The Karachi intracranial stenosis study (KISS) Protocol: an urban multicenter case-control investigation reporting the clinical, radiologic and biochemical associations of intracranial stenosis in Pakistan.

Background: Intracranial stenosis is the most common cause of stroke among Asians. It has a poor prognosis with a high rate of recurrence. No effective medical or surgical treatment modality has been developed for the treatment of stroke due to intracranial stenosis.