Publications by authors named "Karim Merchant"
Article Synopsis
- The study investigates how integrating point of care (POC) echocardiography in managing septic shock affects patient outcomes in the ICU following the Surviving Sepsis Campaign guidelines.
- A total of 1701 articles were reviewed, and after filtering, seven studies with 3885 patients were included, showing that POC echocardiography is linked to lower in-hospital and 28-day mortality rates, more frequent use of inotropic support, and faster lactate clearance.
- The researchers concluded that while POC echocardiography can improve some outcomes in septic shock management, more extensive studies are needed to confirm these findings and explore additional treatment effects.
Background: There is a critical need to develop novel therapies for COVID-19.
Methods: We conducted a phase 2, multicentre, placebo-controlled, double-blind, randomised trial; hospitalised patients with hypoxemic respiratory failure due to COVID-19 and at least one poor prognostic biomarker, were given sirolimus (6 mg on Day 1 followed by 2 mg daily for 14 days or hospital discharge, whichever happens first) or placebo, in a 2:1 randomization scheme favouring sirolimus. Primary outcome was the proportion of patients alive and free from advanced respiratory support measures at Day 28.