Publications by authors named "Karim H"

Background: Food allergy has been shown to negatively impact children's mental health and quality of life. However, its impact on school performance is unknown.

Objective: We aimed to investigate whether food allergy, severe and nonsevere, is associated with school performance when accounting for measured and unmeasured familial factors.

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Background: Evidence suggests a link between food allergy and poor mental health, however, this may be explained by shared genetic and environmental factors. We aimed to investigate the association between food allergy of different severity and mental health in children, and the role of familial factors.

Methods: This population-based, longitudinal cohort study is based on the Child and Adolescent Twin Study in Sweden with questionnaire data reported by parents and/or children.

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Objective: Acute experimental models of antidepressant placebo effects suggest that expectancies, encoded within the salience network (SN), are reinforced by sensory evidence and mood fluctuations. However, whether these dynamics extend to longer timescales remains unknown. To answer this question, we investigated how SN and default mode network (DMN) functional connectivity during the processing of antidepressant expectancies facilitates the shift from salience attribution to contextual cues in the SN to belief-induced mood responses in the DMN, both acutely and long-term.

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The Circle of Willis (CW) is a critical cerebrovascular structure that supports collateral blood flow to maintain brain perfusion and compensate for eventual occlusions. Increased tortuosity of high-risk vessels within the CW has been implicated as a marker in the progression of cerebrovascular diseases especially in structures like the internal carotid artery (ICA). This is partly due to age-related plaque deposition or arterial stiffening.

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Catatonia is a serious neuropsychiatric syndrome of motor and behavioral dysfunction where electroconvulsive therapy (ECT) is a well-proven treatment modality. ECT is also preferred as it is a low-risk procedure compared to chronic medications having significant side effects. However, the cardiovascular events that occur during ECT are a major cause of morbidity and mortality in patients with an abnormal cardiovascular pathophysiology.

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Axonal spheroids are hallmark features of neurodegeneration, forming along degenerating axons and contributing to disease progression. Despite their ubiquity across degenerative etiologies, the dynamics of spheroid disappearance, as well as their interactions with glial cells, remain poorly understood. Here, using an zebrafish model of peripheral nerve injury, we identified several patterns of spheroid disappearance that are regulated by Schwann cells.

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  • Recent advancements in Alzheimer's treatment now require verification of amyloid-β pathology using PET scans or cerebrospinal fluid, but blood tests could simplify this process.* -
  • A study involving nearly 7,000 individuals identified that the plasma biomarker p-tau217 can reliably indicate amyloid-β pathology, especially in patients with probable Alzheimer’s dementia.* -
  • The findings suggest that combining p-tau217 results with clinical assessments may allow for accurate diagnoses without the need for more invasive PET or CSF tests.*
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Introduction: Brain age is a machine learning-derived estimate that captures lower brain volume. Previous studies have found that brain age is significantly higher in mild cognitive impairment and Alzheimer's disease (AD) compared to healthy controls. Few studies have investigated changes in brain age longitudinally in MCI and AD.

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With the advancement of technology, equipment, and airway management knowledge, anticipated difficult airway (DA) management has come a long way towards excellence. Usually, anticipated difficulties are related to bag-mask ventilation (BMV), laryngoscopy, intubation, or supraglottic airway placement; all in a single patient pose exceptionally challenging airway management. We may electively plan a surgical airway, but the option may not be available, especially when the patient provides tracheostomy permission only for emergency airway management, not for an elective.

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  • - Segmental thoracic spinal anesthesia (STSA) has been evaluated mainly through case reports and a few comparative studies, positioning it as a potential alternative to general anesthesia (GA) for patients with significant respiratory issues undergoing abdominal and thoracic surgeries.
  • - A systematic review analyzed data from 394 patients across six studies, revealing that STSA was associated with a significantly higher likelihood of hypotension and bradycardia but a lower likelihood of postoperative nausea and vomiting (PONV) compared to GA.
  • - Despite the higher instances of hypotension and bradycardia, overall patient satisfaction with STSA was comparable to GA, though some surgeons were hesitant to use STSA for specific procedures due to complications like muscle twitches from caut
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  • Late-life depression (LLD) might be linked to changes in brain structure and aging, but this study looked to see if brain age could help predict if someone with LLD would relapse.
  • Researchers studied 102 people with LLD and 43 healthy individuals over two years to see how their brain age compared and if it related to relapsing.
  • The results showed that brain age wasn’t different between healthy people and those with LLD, and it didn’t predict whether someone would relapse, which was unexpected based on previous studies.
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  • People with HIV (PWH) have a higher risk of cardiovascular disease (CVD) compared to those without HIV, and the study aimed to evaluate their adherence to CVD medications and factors influencing non-adherence.
  • Conducted at the University Hospitals of Leicester NHS Trust, this study analyzed data from 162 PWH, with findings indicating that about one-third of patients did not have prescribed medications detected in their urine, particularly highlighting issues with lipid-lowering agents.
  • The analysis showed that a higher number of prescribed medications correlated with non-adherence, emphasizing the need for improved strategies to enhance medication compliance among PWH for better health outcomes.
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  • - Menopause marks the end of menstrual cycles due to decreased reproductive hormone production, occurring after 12 months of no periods, and may be linked to an increased risk of Alzheimer's disease (AD) due to reduced estrogen levels.
  • - Estrogen is important for brain function, affecting energy use and cognitive abilities, and hormone replacement therapy (HRT) might offer cognitive benefits by enhancing estrogen's protective effects on the brain and improving heart health.
  • - While there’s a lot of evidence supporting estrogen's positive effects on brain health, clinical trial results on HRT's benefits for cognitive decline in menopausal women are inconsistent, highlighting the need for more research in this area.
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Agriculture plays a vital role in Bangladesh's economy. It is essential to ensure the proper growth and health of crops for the development of the agricultural sector. In the context of Bangladesh, crop diseases pose a significant threat to agricultural output and, consequently, food security.

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Worry is a transdiagnostic symptom common to many neurocognitive disorders of aging, including early stages of Alzheimer's disease and related dementias (ADRD). Severe worry is associated with amyloid burden in cognitively intact older adults, yet the mechanisms underlying this association are not well understood. We hypothesize that this relationship involves altered brain and cardiovascular reactivity to acute stressors, a brain-body phenotype that also increases risk for cardiovascular disease.

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Background And Aims: Anesthesiologists' services extend to many critical areas of any healthcare setup. However, there needs to be more understanding among the public regarding their crucial role. Preanesthesia evaluation (PAE) visits can disseminate information about anesthesiologists and services.

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Background Perioperative dysglycemia increases morbidity and mortality, particularly among those with diabetes mellitus (DM), and elevated HbA1c levels, reflecting long-term blood glucose, are linked to poor healing and higher infection rates. This study investigates the link between preoperative HbA1c levels and perioperative outcomes in type-2 DM patients. Methodology This prospective observational study was conducted in India between January 2021 and April 2022.

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Although low-flow anesthesia is widely used due to its various advantages, there are concerns about potential and relative hypoxia. Furthermore, oxygen is also a drug with benefits and adverse effects. We aimed to evaluate and compare the effect of real-time oxygen consumption versus fixed flow-based low flow anesthesia on oxygenation and perfusion and to compare the economic benefits.

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Background: In the search for opioid-free anesthesia, notable numbers of drugs, singly or in combinations, have been tested with variable results. However, most of the drugs used are not as strong as opioids. Even if some non-opioid drugs are potent enough, they cause significant untoward effects, necessitating the use of lower effective dosages of multiple drugs as a substitute.

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