Synthesis of High-Purity Hydroxyapatite and Phosphoric Acid Derived from Moroccan Natural Phosphate Rocks by Minimizing Cation Content Using Dissolution-Precipitation Technique.

This study investigates, in the first part, the synthesis and purification of a poorly crystalline hydroxyapatite (HAp) using natural Moroccan phosphate (Boucraa region) as a raw material. Despite its successful preparation, the obtained HAp was contaminated by several metallic cations (mostly Cd, Pb, Sn, Ti, Mn, Mg, Fe, and Al) migrated from the natural rocks during the digestion process, inhibiting HAp application in several sectors. To minimize the existence of these elements, the dissolution-precipitation technique (DP) was investigated as a non-selective purification process.

Loaded n-Hydroxyapatite/SSG 3D Scaffolds as a Drug Delivery System of Fractions for the Management of Local Antibacterial Infections.

As a result of their close similarities to the inorganic mineral components of human bone, hydroxyapatite nanoparticles (n-HAp) are widely used in biomedical applications and for the elaboration of biocompatible scaffold drug delivery systems for bone tissue engineering. In this context, a new efficient and economic procedure was used for the consolidation of n-HAp in the presence of various () fractions at a near-room temperature. The research conducted in the present study focuses on the physicochemical properties of loaded n-HAp 3D scaffolds by fractions and the in vitro antibacterial activity against Gram-negative ( ATCC 25922, ATCC 27853, ATCC 27853), and Gram-positive ( ATCC 29213, ATCC 700603) bacteria.