Cerebral small vessel disease due to a unique heterozygous mutation in an African man.

Objective: To describe the case of an African patient who was diagnosed with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL).

Methods: Case report and literature review.

Results: We present a 39-year-old Gabonese man who developed progressive gait difficulty at the age of 32, followed by insidious tetraparesis, urinary sphincter disturbance, spastic dysarthria, cognitive dysfunction, and seizures.

Thoracic myelopathy caused by ossification of the ligamentum flavum: a report of 18 cases.

Object: Thoracic myelopathy caused by ossification of the ligamentum flavum (OLF) is a rare entity, most evident in Japan. The authors studied the clinical manifestations, radiological aspects, surgical treatment, and pathogenesis of this disease.

Methods: Eighteen patients with OLF-induced thoracic myelopathy underwent laminectomy.