Publications by authors named "Kari Murdy"
Familial hypercholesterolemia (FH) is an inherited condition resulting in increased risk of premature cardiovascular disease. This risk can be reduced with early diagnosis and treatment, but it can be challenging to identify individuals with FH. Cascade screening, the most efficient and cost-effective identification method, requires FH patients to communicate with their at-risk family and encourage them to pursue screening.
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- The study investigates how childhood BMI, fasting glucose, and insulin levels can predict the onset of type 2 diabetes mellitus (T2DM) in adulthood.
- The research analyzed data from a large cohort of 6,738 participants who were followed from childhood into their 40s, revealing that higher childhood BMI and glucose levels increased the risk of developing T2DM by age 30.
- The findings suggest that even childhood measurements considered normal can indicate later diabetes risk, making them useful for clinical assessments, while fasting insulin may also serve as an additional predictor.
Background: Early diagnosis and treatment of familial hypercholesterolemia reduces patient morbidity and mortality associated with coronary heart disease. Despite guidelines recommending screening of all pediatric patients aged 9 to 11 years, universal screening rates are reportedly low. Evaluating current screening practices provides key insights to inform and improve screening rates in the future.
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