Non-dispensed prescriptions - A nationwide descriptive study.

Background: Medication non-adherence is associated with suboptimal health outcomes, higher mortality, and increased healthcare costs.

Objective: The aim of this study was to estimate the number and share of non-dispensed prescriptions at a national level and in specific patient and medicine subgroups.

Methods: The study was a nationwide retrospective register-based study.

Synthesis and properties of phosphorus nanostructures on Au(110).

Phosphorene, a semiconducting two-dimensional material, has recently attracted huge interest due to its potential applications in opto-electronics. The first attempts to synthesize phosphorene were based mainly on mechanical and chemical exfoliations. A few years later, different groups reported the synthesis of phosphorene using the molecular beam epitaxy process, which opened the way for research on physical properties.

Outpatient antibiotic prescribing during the first two years of the COVID-19 pandemic: A nationwide register-based time series analysis.

The COVID-19 pandemic has imposed an enormous burden on health care systems around the world. Simultaneously, many countries have reported a decrease in the incidence of other infectious diseases, such as acute respiratory infections, leading to a decline in outpatient antibiotic use. The aim of this study is to assess the impact of the COVID-19 pandemic on outpatient antibiotic prescribing in Finland during the first 2 years of the pandemic.

Medicine shortages: Product life cycle phases and characteristics of medicines in short supply-A register study.

Product life cycle refers to all phases of a product from development to active market phase and finally the phase in which products possibly exit the market. The product life cycle of medicines in short supply has not been studied in depth, although there is some indication of mature products and products with lower prices and profit margins being exposed to shortages more often. The aim of this study was to examine the product life cycle phases and characteristics of medicines in short supply as well as the features of medicine shortages in Finland from 2017 to 2019.

Developing an interprofessional people-centred care model for home-living older people with multimorbidities in a primary care health centre: A community-based study.

Background: The ageing population with multiple conditions and complex health needs has forced healthcare systems to rethink the optimal way of delivering services. Instead of trying to manage numerous diseases in a siloed approach, the emphasis should be on people-centred practice, in which healthcare services are tailored to people's needs and provided in partnership with them.

Objective: The aim was to develop an interprofessional people-centred care model (PCCM), including the contribution of a clinically trained pharmacist for home-living multimorbid older people in primary care.

DeePromClass: Delineator for Eukaryotic Core Promoters Employing Deep Neural Networks.

Computational promoter identification in eukaryotes is a classical biological problem that should be refurbished with the availability of an avalanche of experimental data and emerging deep learning technologies. The current knowledge indicates that eukaryotic core promoters display multifarious signals such as TATA-Box, Inr element, TCT, and Pause-button, etc., and structural motifs such as G-quadruplexes.

Effectiveness and cost-effectiveness of a people-centred care model for community-living older people versus usual care ─ A randomised controlled trial.

Background: There is a need for effective and cost-effective interprofessional care models that support older people to maintain their quality of life (QoL) and physical performance to live longer independently in their own homes.

Objectives: The objectives were to evaluate effectiveness, QoL and physical performance, and cost-utility of a people-centred care model (PCCM), including the contribution of clinically trained pharmacists, compared with that of usual care in primary care.

Methods: A randomised controlled trial (RCT) with a two-year follow-up was conducted.

Patient involvement is essential in identifying drug-related problems.

Aims: The aim of this study is to evaluate how critical patient involvement is in pharmacist-led clinical medication reviews and in identifying the most significant clinical drug-related problems (DRPs).

Methods: Pharmacist-led clinical medication reviews were conducted with 161 consenting patients aged ≥75 years with at least seven prescribed medicines, living independently at home in Finland. A pharmacist, a nurse and a physician evaluated the clinical significance of the DRPs identified during the patient interview at an interprofessional case conference.

Silent lipreading and covert speech production suppress processing of non-linguistic sounds in auditory cortex.

Previous studies have suggested that speech motor system mediates suppression by silent lipreading of electromagnetic auditory cortex responses to pure tones at about 100 ms from sound onset. We used sparse sampling functional magnetic resonance imaging (fMRI) at 3 Tesla to map auditory-cortex foci of suppressant effects during silent lipreading and covert self-production. Streams of video clips were presented simultaneously with 1/3 octave noise bursts centered at 250 Hz (low frequency, LF) or 2000 Hz (mid-frequency, MF), or during no auditory stimulation.

Effects of ketamine on brain monoamine levels in rats.

The effects of ketamine (50 mg/kg i.p.) on brain monoamines, including epinephrine, norepinephrine, dopamine, serotonin and its metabolite 5-hydroxy indoleacetic acid, were studied in three groups of male Sprague-Dawley rats.