Synopsis of recent research by authors named "Kari A Schick"
- Kari A Schick's research primarily focuses on the energetics of antibody interactions, particularly examining the differences between cross-reactive and specific antibodies.
- In the study titled "Association energetics of cross-reactive and specific antibodies," Schick investigates murine monoclonal IgG(1) antibodies that exhibit high amino acid sequence identity while differing significantly in their reactivity to epitope mutations.
- The findings reveal that while the antibody HH8 displays high cross-reactivity, the more rigid HH26 exhibits strong specificity, highlighting the influence of structural features and intramolecular interactions on antibody behavior.