Postmortem analyses of myocardial microRNA expression in sepsis.

Background: Sepsis can lead to myocardial depression, playing a significant role in sepsis pathophysiology, clinical care, and outcome. To gain more insight into the pathophysiology of the myocardial response in sepsis, we investigated the expression of microRNA in myocardial autopsy specimens in critically ill deceased with sepsis and non-septic controls.

Materials And Methods: In this retrospective observational study, we obtained myocardial tissue samples collected during autopsy from adult patients deceased with sepsis (n = 15) for routine histological examination.

The bidirectional relationships of optimism and pessimism with depressive symptoms in adulthood - A 15-year follow-up study from Northern Finland Birth Cohorts.

Background: Low optimism and high pessimism have predicted depressive symptoms in several studies, but the associations in the other direction, from depressive symptoms to future optimism and pessimism, have been unexplored. We examined bidirectional associations of optimism and pessimism with depressive symptoms in adulthood.

Methods: A population-based sample of 4011 Finnish adults (55 % women) was analyzed with a 15-year prospective follow-up period from age 31 to age 46.

Unresponsive Low Mixed Venous Oxygen Saturation During Early Intensive Care Unit Stay is Associated With Increased Risk of Organ Dysfunction After Cardiac Surgery: A Single-Center Retrospective Study.

Objectives: The aim of the study was to determine if unresponsive mixed venous oxygen saturation (SvO) values during early postoperative hours are associated with postoperative organ dysfunction.

Design: A single-center retrospective observational study.

Setting: A university hospital.

Protocol for mapping of the supplementary motor area using repetitive navigated transcranial magnetic stimulation.

Background: Damage to the supplementary motor area (SMA) can lead to impairments of motor and language function. A detailed preoperative mapping of functional boarders of the SMA could therefore aid preoperative diagnostics in these patients.

Objective: The aim of this study was the development of a repetitive nTMS protocol for non-invasive functional mapping of the SMA while assuring effects are caused by SMA rather than M1 activation.

Impacts on water quality in the peatland dominated catchment due to foreseen changes in Nordic Bioeconomy Pathways.

The Nordic Bioeconomy Pathways (NBPs), conceptualized subsets of Shared Socioeconomic Pathways varying from environmentally friendly to open-market competition scenarios, can lead to plausible stressors in future for using bioresources. This study analysed the impacts of NBPs on hydrology and water quality based on two different land system management attributes: management strategy and a combination of reduced stand management and biomass removal at a catchment-scale projection. To understand the potential impacts of NBPs, the Simojoki catchment in northern Finland was chosen, as the catchment mainly covered peatland forestry.

Cantilever-enhanced photoacoustic measurement of HTO in water vapor.

A photoacoustic detection of tritiated water (HTO) is presented. The method uses cantilever-enhanced photoacoustic spectroscopy (CEPAS) to reach sub-ppb sensitivity for HTO in the gas phase. A noise equivalent concentration of 0.

The interrogator-suspect dynamic in custodial interrogations for high-stakes crimes in Sweden: An application of the interrogation taxonomy framework.

This archival study was the first in Sweden, and the first outside of the US and the UK, to apply the (Kelly et al., Psychology, Public Policy, and Law, 9, 165-178, 2013) taxonomy of interrogation methods framework to repeated police interrogations of adult suspects in high-stakes crimes. Audio/video recordings (N = 19) were collected from the Swedish Police Authority of repeated interrogations of three suspects in three criminal cases.

Association of low mixed venous oxygen saturations during early ICU stay with increased 30-day and 1-year mortality after cardiac surgery: a single-center retrospective study.

Background: Low postoperative mixed venous oxygen saturation (SvO) values have been linked to poor outcomes after cardiac surgery. The present study was designed to assess whether SvO values of < 60% at intensive care unit (ICU) admission and 4 h after admission are associated with increased mortality after cardiac surgery.

Methods: During the years 2007-2020, 7046 patients (74.

Land use synergies and conflicts identification in the framework of compatibility analyses and spatial assessment of ecological, socio-cultural and economic values.

Land-use conflicts can be costly and time-consuming and cause social burden to all parties. In this study, we developed an approach for mapping synergy and conflict potential between land uses and tested it on nature protection, nature-based tourism, forestry and mining. First, we calculated the ecological and socio-cultural values for the study area, and further the economic values related to forestry and mining.

Enhancement of photoacoustic spectroscopy with sorption enrichment for ppt-level benzene detection.

A real-time trace gas detector for benzene is demonstrated. The measurement system takes advantage of modest enrichment through short adsorption periods to reach a ppt-level detection limit with a sampling cycle of 90 s, which includes sample adsorption, desorption, and a spectroscopic measurement. Benzene is collected on Tenax TA sorbent for 30 s and then detected from the enriched samples with photoacoustic spectroscopy.

Cochlear implantation of a patient with multiple sclerosis: case report and systematic review.

Background: Cochlear implantation can be used when a patient's hearing cannot satisfactorily be improved after optimised hearing aid fitting. However, in patients with a cochlear nerve or brain disorder affecting hearing, the benefits of cochlear implants are not so straightforward.

Methods: This paper describes a 58-year-old patient suffering from multiple sclerosis and profound sensorineural hearing loss, rehabilitated with a cochlear implant.

LED-Based Photoacoustic NO Sensor with a Sub-ppb Detection Limit.

A high-sensitivity light-emitting diode (LED)-based photoacoustic NO sensor is demonstrated. Sensitive photoacoustic gas sensors based on incoherent light sources are typically limited by background noise and drifts due to a strong signal generated by light absorbed at the photoacoustic cell walls. Here, we reach a sub-ppb detection limit and excellent stability using cantilever-enhanced photoacoustic detection and perform a two-channel relative measurement.

Mid-infrared frequency comb with 25 pJ threshold via CW-seeded optical parametric generation in nonlinear waveguide.

We demonstrate efficient generation of mid-infrared frequency combs based on continuous-wave-seeded femtosecond optical parametric generation in nonlinear waveguides. Conversion of the near-infrared pump to signal and idler light takes place with very high efficiency (74%), and the threshold (25 pJ for 100 fs pulses) is over 300 times lower than in bulk analogs. Relative intensity noise of the mid-infrared comb is exceptionally low, below 5×10 (integrated from 10 Hz to 2 MHz).

Radiocarbon dioxide detection using cantilever-enhanced photoacoustic spectroscopy.

In this Letter, we report on the sub-parts-per-billion-level radiocarbon dioxide detection using cantilever-enhanced photoacoustic spectroscopy. The / ratio of samples is measured by targeting a absorption line with minimal interference from other isotopes. Using a quantum cascade laser as a light source allows for a compact experimental setup.

Sub-ppb detection of benzene using cantilever-enhanced photoacoustic spectroscopy with a long-wavelength infrared quantum cascade laser.

We report a novel, to the best of our knowledge, photoacoustic spectrometer for trace gas sensing of benzene. A quantum cascade laser emitting at the wavelength 14.8 µm is used as the light source in the spectroscopic detection.

Brain Response Induced with Paired Associative Stimulation Is Related to Repetition Suppression of Motor Evoked Potential.

Repetition suppression (RS), i.e., the reduction of neuronal activity upon repetition of an external stimulus, can be demonstrated in the motor system using transcranial magnetic stimulation (TMS).

Thalamic Atrophy Predicts 5-Year Disability Progression in Multiple Sclerosis.

Thalamus is among the first brain regions to become atrophic in multiple sclerosis (MS). We studied whether thalamic atrophy predicts disability progression at 5 years in a cohort of Finnish MS patients. Global and regional brain volumes were measured from 24 newly diagnosed relapsing MS (RMS) patients 6 months after initiation of therapy and from 36 secondary progressive MS (SPMS) patients.

Finnish National Phenological Network 1997-2017: from observations to trend detection.

Plant phenological dataset collected at 42 sites across the mainland of Finland and covering the years 1997-2017 is presented and analysed for temporal trends. The dataset of n = 16,257 observations represents eleven plant species and fifteen phenological stages and results in forty different variables, i.e.

Minimal biomass deposition in banded iron formations inferred from organic matter and clay relationships.

The cycling of iron and organic matter (OM) is thought to have been a major biogeochemical cycle in the early ferruginous oceans which contributed to the deposition of banded iron formations (BIF). However, BIF are deficient in OM, which is postulated to be the result of near-complete oxidation of OM during iron reduction. We test this idea by documenting the prevalence of OM in clays within BIF and clays in shales associated with BIF.

Interaction between repetition suppression in motor activation and long-interval intracortical inhibition.

Repetition suppression (RS) is the adaptation of the neural activity in response to a repeated external stimulus. It has been proposed that RS occurs at the thalamo-cortical level, hence activating a feedback loop to the cortex in order to counteract with the repeated motor cortical activation. In this study, to elucidate the common modulators between the RS and the inhibitory/facilitatory cortical networks, two TMS paradigms were applied, i.

Thalamic Atrophy Without Whole Brain Atrophy Is Associated With Absence of 2-Year NEDA in Multiple Sclerosis.

To study which brain volume measures best differentiate early relapsing MS (RMS) and secondary progressive MS (SPMS) patients and correlate with disability and cognition. To test whether isolated thalamic atrophy at study baseline correlates with NEDA (no evidence of disease activity) at 2 years. Total and regional brain volumes were measured from 24 newly diagnosed RMS patients 6 months after initiation of therapy and 2 years thereafter, and in 36 SPMS patients.

Broadband photoacoustic spectroscopy of CH14 with a high-power mid-infrared optical frequency comb.

We report a photoacoustic spectroscopy setup with a high-power mid-infrared frequency comb as the light source. The setup is used in broadband spectroscopy of radiocarbon methane. Owing to the high sensitivity of a cantilever-enhanced photoacoustic cell and the high-power light source, we can reach a detection limit below 100 ppb in a broadband measurement with a sample volume of only a few milliliters.

Cortical Inhibition of Face and Jaw Muscle Activity and Discomfort Induced by Repetitive and Paired-Pulse TMS During an Overt Object Naming Task.

Modulatory effects of transcranial magnetic stimulation (TMS) strongly depend on the stimulation parameters. Here, we compared the immediate, task-locked inhibitory effects on speech-related muscles and the tolerability of different TMS protocols during a language production task. Repetitive TMS (rTMS) and paired-pulse TMS (PP) were applied in 13 healthy subjects over the primary motor cortex (M1) during a finger-tapping/tongue-twisting tasks.

Step-modulated decay cavity ring-down detection for double resonance spectroscopy.

A method of measuring double resonant two-photon signal and background from a single cavity ring-down decay is introduced. This is achieved by modulating the double resonance loss via one of the light sources exciting the transition. The noise performance of the method is characterized theoretically and experimentally.